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Fabrice Cognasse: Improving Hemorrhagic Resuscitation Through Better Understanding of LTOWB
Fabrice Cognasse/LinkedIn
Jul 16, 2026, 00:13

Fabrice Cognasse: Improving Hemorrhagic Resuscitation Through Better Understanding of LTOWB

Fabrice Cognasse, Director of Research – Scientific Director at The EFS in Auvergne-Rhône-Alpes and INSERM, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Intensive Care Medicine Experimental, adding:

”New publication!

We are pleased to share our latest study published in Intensive Care Medicine Experimental (CTSA, EFS Inserm SAnté INgéniérie BIOlogie St-Etienne (SAINBIOSE) Ministère des Armées):

Dynamics of platelet activation in cold-stored low-titer group O whole blood over 8 days: insights relative to standard platelet concentrates

As the use of low-titer group O whole blood (LTOWB) continues to expand in trauma and critical care, understanding the biology of platelets during refrigerated storage has become increasingly important.

Aim: To characterize the platelet activation phenotype of cold-stored LTOWB and compare it with standard platelet concentrates throughout 8 days of storage.

Key findings: LTOWB exhibits a distinct platelet activation profile, with progressive basal activation during cold storage while maintaining robust agonist-induced responses through Day 8.

Why does it matter?

These findings provide new insights into the biology of LTOWB and support future studies investigating how storage-related platelet changes may influence hemostasis, immunothrombosis, endothelial interactions, and transfusion-associated lung injury in hemorrhagic resuscitation.

Congratulations to all co-authors and collaborators for this exciting multidisciplinary work!”

Title: Dynamics of platelet activation in cold-stored low-titer group O whole blood over 8 days: insights relative to standard platelet concentrates

Authors: Fabrice Cognasse, Karine Desseux, Véronique Artero, Véronique Duraffourg, Charles-Antoine Arthaud, Amélie Prier, Marie-Ange Eyraud, Victorine Maillot, Damien Crespe, Christophe Martinaud, Sylvain Ausset, Pierre Tiberghien, Laurent Aoustin, Patricia Chavarin, Sébastien Banzet, Nadira Frescaline, Hind Hamzeh-Cognasse

Fabrice Cognasse: Improving Hemorrhagic Resuscitation Through Better Understanding of LTOWB

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Amelie Prier Charles-Antoine Arthaud Christophe Martinaud Damien Crespe Fabrice Cognasse Health Hematology Hemostasis Hemostasis News Hemostasis Today Hind Hamzeh-Cognasse Intensive Care Medicine Experimental Karine Desseux Laurent Aoustin LTOWB Marie-Ange Eyraud Medicine Nadira Frescaline Patricia Chavarin Pierre Tiberghien platelets Sébastien Banzet Sylvain Ausset thrombosis Transfusion Medicine Véronique Artero Véronique Duraffourg Victorine Maillot
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