Lindsey George: Understanding the Enhanced Activity of FVIII Aurora
Lindsey George, Assistant Professor of Pediatrics at University of Pennsylvania, Director of Clinical In Vivo Gene Therapy at Children’s Hospital of Philadelphia, shared on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:
”Congratulations Johnathan Morris!
This manuscript describes the underlying mechanism of FVIII Aurora (FVIII-R571S), which has 10–20-fold higher affinity for FIXa over FVIII-WT and FIXa-dependent reduced inactivation by A2-domain dissociation and APC cleavage.”
Title: Factor VIII Aurora: A Naturally Occurring Gain of Function FVIII Variant with Enhanced FIXa Affinity
Authors: Johnathan J. Morris, Robert J Davidson, Connor T. Watson, Lindsey A. George
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