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Davide Capodanno Shares FITTER Trial: Evolocumab Shows No Added Short-Term Benefit in Acute Coronary Syndrome
Davide Capodanno/X
Aug 18, 2025, 23:54

Davide Capodanno Shares FITTER Trial: Evolocumab Shows No Added Short-Term Benefit in Acute Coronary Syndrome

Davide Capodanno, professor of Cardiology at University of Catania, editor-in-Chief of EuroIntervention, posted on X:

”In the double-blind, randomized FITTER trial, 150 patients with acute coronary syndrome and relevant non-culprit lesions received evolocumab or placebo for 12 weeks in addition to high-intensity statin therapy.

PCSK9 inhibition did not produce additional short-term improvements in plaque lipid content, plaque volume, or coronary physiology.”

Read the full article here.

Find the editorial here.

Article: Changes in non-culprit coronary lesions with PCSK9 inhibitors: the randomised, placebo-controlled FITTER trial

Authors: Frans B. Mensink, Jonathan Los, Mohamed M. Reda Morsy, Rohit M. Oemrawsingh, Clemens von Birgelen, Alexander J.J. Ijsselmuiden, Martijn Meuwissen, Jin M. Cheng, Diederik F. van Wijk, Pieter C. Smits, Valeria Paradies, Dirk J. van Wijk, Himanshu Rai, Tim J.F. ten Cate, Cyril Camaro, Peter Damman, Lokien X. van Nunen1, Aukelien C. Dimitriu-Leen, Marleen H. van Wely, Aysun Cetinyurek-Yavuz, Robert A. Byrne, Niels van Royen, Robert-Jan M. van Geuns

Davide Capodanno Shares FITTER Trial: Evolocumab Shows No Added Short-Term Benefit in Acute Coronary Syndrome

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acute coronary syndrom Acute coronary syndrome Alexander J.J. Ijsselmuiden Aukelien C. Dimitriu-Leen Aysun Cetinyurek-Yavuz Cardiology Clemens von Birgelen Coronary Syndrome Cyril Camaro Davide Capodanno Diederik F. van Wijk Dirk J. van Wijk EuroIntervention Evolocumab FITTER FITTER trial Frans B. Mensink Haemostasis Today Health Hematology Hemostasis Today Himanshu Rai Jin M. Cheng Jonathan Los Lokien X. van Nunen1 Marleen H. van Wely Martijn Meuwissen Medicine Mohamed M. Reda Morsy Niels van Royen PCSK9 inhibitors Peter Damman1 Pieter C. Smits Robert A. Byrne Robert-Jan M. van Geuns Rohit M. Oemrawsingh statins Tim J.F. ten Cate University of Catania Valeria Paradies
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