Platelets Show Distinct Molecular Changes in Active ITP – JTH
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Julia-Annabell Georgi et al., adding:
“RNA sequencing indicates distinct platelet transcriptomic changes in immune thrombocytopenia
Platelets keep a working transcriptome despite lacking a nucleus, and in active immune thrombocytopenia that profile looked distinct.
RNA sequencing showed coordinated upregulation of platelet activation pathways, including integrin and calcium signaling and cytoskeletal remodeling, alongside reduced mitochondrial and oxidative phosphorylation genes.
This activation-primed, metabolically altered signature was unique to active ITP and partly normalized in treatment-free remission.”
Title: RNA sequencing indicates distinct platelet transcriptomic changes in immune thrombocytopenia
Authors: Julia-Annabell Georgi, Marita Hartwig, Ulrike Anne Friedrich, Maximilian Krause, Andreas Dahl, Heidi Altmann, Thomas Stauch, Jan Moritz Middeke, Martin Bornhäuser, Peter Bugert, Christian Thiede, Karolin Trautmann-Grill
Other posts about Journal of Thrombosis and Haemostasis on Hemostasis Today.
-
Aug 8, 2026, 08:37Kim Phelan: Voices of the Symposium 2026
-
Aug 8, 2026, 08:29Abdulrahman Nasiri: Understanding and Managing Chronic Pain in Transfusion-Dependent Thalassemia
-
Aug 8, 2026, 07:59Call for Papers – Thrombosis and Antithrombotic Therapy – Korawit Juprasertporn
-
Aug 8, 2026, 07:13Myth vs Fact – ‘An ITP diagnosis means life stops’ – ITP Support Association
-
Aug 8, 2026, 07:08Andrew Jackson: Clinical Characteristics and Antibiotic Resistance Patterns of Hemodialysis CRBSIs
-
Aug 8, 2026, 06:51New Data on Iron Chelation in Thalassemia – Arslan Liaqat
-
Aug 8, 2026, 06:31A New European Programme in Clinical Haemostasis – CRH French Reference Center for Hemophilia Lyon
-
Aug 8, 2026, 05:23Mohsin Naseer։ From Beginner to Published Researcher
-
Aug 8, 2026, 04:50Marc Carrier: Celebrating 20 Years with ASH CRTI