Maria Cherska: Lipid Metabolism and Immune Remodeling in Metastatic Colorectal Cancer
Maria Cherska, The Head of Cardiology Department at The State Institution V.P. Komisarenko Institute of Endocrinology and Metabolism, shared a post on LinkedIn about a recent article by Yuru Shang et al., published in Lipids in Health and Desease, adding:
“Lipid metabolism is emerging as a new frontier in cancer research.
A new review in Lipids in Health and Disease highlights how lipid metabolic reprogramming can reshape the immune microenvironment in metastatic colorectal cancer—affecting T-cell exhaustion, immune escape, ferroptosis, and therapeutic response.
Key pathways include FASN, CD36, HMGCR, PCSK9, and SREBP, opening intriguing possibilities for combining metabolic targeting with immunotherapy.
From cardiovascular biology to precision oncology — lipids matter.”
Title: Lipid metabolism as a central driver of immune remodeling and therapeutic vulnerability in metastatic colorectal cancer
Authors: Yuru Shang, Qingxi Yang, Runlin Zhang, Weiguo Xu, A. M. Abd El-Aty, Yu Gao and Tianbao Wang
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