Stelios Andreadis։ Human Salivary Gland Organoids Offer New Potential for Regenerative Medicine
Stelios Andreadis, Director, Center for Cell, Gene and Tissue Engineering (CGTE) at University at Buffalo, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Nature Communications, adding:
”This one has been cooking for a long time, and I’m especially excited to finally see it published in Nature Communications!
Our team developed a method to generate salivary gland progenitor cells from human pluripotent stem cells by recreating key steps of normal gland development.
In 3D hydrogels, these cells self-organized into salivary gland organoids, or ‘mini-organs,’ with important structural and functional features of native tissue.
Even more exciting, when transplanted into injured salivary glands in mice, the human organoids integrated into the host tissue and gave rise to all three major salivary gland cell types: acinar, ductal, and myoepithelial cells.
This work highlights the potential of these organoids not only for regenerative medicine, but also as human models for studying disease and testing therapies aimed at restoring salivary gland function after radiation treatment for head and neck cancer or in autoimmune diseases such as Sjögren’s disease.
A huge congratulations to Laura Sherwood, an NIH F31 fellow, and Ronel Samuel, now a postdoctoral fellow at the University of Pennsylvania, who spearheaded this work; Sai Harsha B. Bhamidipati, who led the bioinformatics analysis with help from Yali Zhang, Jianmin Wang, in the Song Liu laboratory at Roswell Park Comprehensive Cancer Center Park Cancer Center; and Kihoon Nam, Frank Maslow and Travis Small in the Olga Baker laboratory at University of Missouri-Columbia, who performed the transplantation studies.
Very proud of this collaborative effort and of everyone who helped bring it across the finish line.”
Title: Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells
Authors: Laura J. Sherwood, Ronel Z. Samuel, Sai Harsha Bhamidipati, Kihoon Nam, Frank Maslow, Travis Small, Yali Zhang, Jianmin Wang, Song Liu, Olga J. Baker, Stelios T. Andreadis
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