Stelios Andreadis։ Human Salivary Gland Organoids Offer New Potential for Regenerative Medicine
Stelios Andreadis, Director, Center for Cell, Gene and Tissue Engineering (CGTE) at University at Buffalo, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Nature Communications, adding:
”This one has been cooking for a long time, and I’m especially excited to finally see it published in Nature Communications!
Our team developed a method to generate salivary gland progenitor cells from human pluripotent stem cells by recreating key steps of normal gland development.
In 3D hydrogels, these cells self-organized into salivary gland organoids, or ‘mini-organs,’ with important structural and functional features of native tissue.
Even more exciting, when transplanted into injured salivary glands in mice, the human organoids integrated into the host tissue and gave rise to all three major salivary gland cell types: acinar, ductal, and myoepithelial cells.
This work highlights the potential of these organoids not only for regenerative medicine, but also as human models for studying disease and testing therapies aimed at restoring salivary gland function after radiation treatment for head and neck cancer or in autoimmune diseases such as Sjögren’s disease.
A huge congratulations to Laura Sherwood, an NIH F31 fellow, and Ronel Samuel, now a postdoctoral fellow at the University of Pennsylvania, who spearheaded this work; Sai Harsha B. Bhamidipati, who led the bioinformatics analysis with help from Yali Zhang, Jianmin Wang, in the Song Liu laboratory at Roswell Park Comprehensive Cancer Center Park Cancer Center; and Kihoon Nam, Frank Maslow and Travis Small in the Olga Baker laboratory at University of Missouri-Columbia, who performed the transplantation studies.
Very proud of this collaborative effort and of everyone who helped bring it across the finish line.”
Title: Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells
Authors: Laura J. Sherwood, Ronel Z. Samuel, Sai Harsha Bhamidipati, Kihoon Nam, Frank Maslow, Travis Small, Yali Zhang, Jianmin Wang, Song Liu, Olga J. Baker, Stelios T. Andreadis
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 20, 2026, 14:32Paul Cane: Antenatal Haemoglobinopathy Screening From Laboratory Testing to Family Care
-
Sep 20, 2026, 14:14New Insights Into Platelet Production in Glanzmann Thrombasthenia – Glanzmann’s Research Foundation
-
Sep 20, 2026, 13:29Factor XI Deficiency and the Challenge of Unpredictable Bleeding – EHC
-
Sep 20, 2026, 13:18Cindy Howry: FDA Approves First Treatment for Ataxia-Telangiectasia
-
Sep 20, 2026, 13:08Mohammad Salar Amoli: When Routine Coagulation Tests Miss von Willebrand Disease
-
Sep 20, 2026, 12:43Obi Light Ogbonnia: Takeaways from the 3rd Global Sickle Cell Disease Conference Nairobi
-
Sep 20, 2026, 12:34Sabrine Mekni: Advancing HSCT for Children With Fanconi Anemia
-
Sep 20, 2026, 12:11Giacomo Buso: Silent Atherosclerosis Begins Earlier Than Expected
-
Sep 20, 2026, 12:0310 Posts Not to Miss This Week