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Rajnikant Patel: Bridging Ayurvedic Concepts and Modern Toxin-Mediated Disease

Rajnikant Patel/LinkedIn

Sep 29, 2026, 17:31

Rajnikant Patel: Bridging Ayurvedic Concepts and Modern Toxin-Mediated Disease

Rajnikant Patel, Senior Ayurvedic Consultant at Jiva Ayurveda, shared a post on LinkedIn:

”What if one of Ayurveda’s oldest clinical disciplines—Visha Chikitsa—has a much more contemporary relevance than we usually recognize?

A 29-year-old woman presented with a severe Hemolytic Uremic Syndrome (HUS).

Her initial condition was critical:

Hemoglobin: 3 g/dL
Platelets: 25,000/µL
Serum creatinine: 3.5 mg/dL
High-grade fever with rigors
Orange-colored urine
8 sessions of dialysis plus 6 plasma therapies

Despite initial management, her hemoglobin again dropped, thrombocytopenia recurred, and the urine again became orange-colored.

She was subsequently referred for Ayurvedic management.

What happened next?

Ayurvedic treatment was initiated based on the clinical understanding of the condition through the lens of Visha Chikitsa.

Treatment:

Shirish Tvak choorna
Vilwadi gulika
Vastiamyantik ghrita
Nagarjunabhra rasa
Over approximately 2 months:

Hemoglobin increased from approximately 7.0–8.0 g/dL to 12.3–12.7 g/dL.

Platelets increased from approximately 61,000–97,000/µL to 201,000–211,000/µL.

Serum creatinine, previously around 3.5 mg/dL, subsequently remained in the range of 1.3–2.6 mg/dL.

Clinically, the patient recovered sufficiently to resume her routine day-to-day activities without significant disturbance.

But here is the part that interests me most…

Modern medicine describes an important form of HUS as a toxin-mediated disease.

In Shiga-toxin–associated HUS, bacterial toxins can injure vascular endothelium. The toxin interacts with Gb3 receptors, which are highly expressed in renal microvascular tissue, contributing to endothelial injury, platelet activation and microvascular thrombosis—ultimately producing the characteristic triad of:

Hemolytic anemia plus thrombocytopenia plus acute kidney injury.

And Ayurveda has an entire clinical discipline devoted to understanding the effects of Visha — toxic substances and their systemic consequences.

This raises a fascinating question:

Can classical Ayurvedic concepts such as Visha Chikitsa provide useful conceptual frameworks for understanding modern toxin-mediated and infection-associated diseases?