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Lorenz Räber: Intracoronary Imaging in PCI – Why, When, How, and Which Modality?
Sep 29, 2026, 22:41

Lorenz Räber: Intracoronary Imaging in PCI – Why, When, How, and Which Modality?

Lorenz Räber, Vice President of Swiss Society of Cardiology, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Nature Reviews Cardiology, adding:

“Intracoronary imaging in PCI: Why, when, how—and which modality? Insights from large randomized controlled trials

Our review has just been published in Nature reviews cardiology, part of Springer Nature

The publication of eight large international randomized controlled trials (each including more than 1,000 patients)—ILUMIEN IV, IVUS-ACS, IVUS-CHIP, IVUS-XPL, OCCUPI, OCTOBER, RENOVATE-COMPLEX, and ULTIMATE—has generated substantial evidence supporting the clinical use of intracoronary imaging (ICI) to improve outcomes in patients undergoing PCI.

However, heterogeneity in study populations, the lack of standardized criteria across ICI-guided PCI protocols, and mixed results across randomized trials have left important uncertainty regarding why, when, and in whom ICI guidance provides the greatest clinical benefit in daily practice.

In this 20-page review, we discuss all major randomized controlled trials of intracoronary imaging guidance—including the latest IVUS-CHIP and OPTIMAL—and provide a practical perspective on the optimal use of IVUS and OCT in contemporary PCI.

A big thanks to Flavio Biccirè (former Bern fellow, now Interventional Consultant at San Giovanni Addolorata, Rome) for his great endurance and commitment throughout this endeavour, and to all our co-author colleagues from Spain, Korea and USA who contributed to this work.

  • Professor Ik-Kyung Jang from Boston Massachusetts General Hospital, Boston, USA
  • Nieves Gonzalo from Hospital Clinico San Carlos, Computense de Madrid University, Madrid, Spain
  • Professor Joo-Yong Hahn from Samsung Medical Center, Sungkyunkwan University, Seol, Korea

Thanks to Dr Gregory Lim for his editorial guidance.”

Title: Intracoronary imaging in percutaneous coronary intervention: why, when, how and which from large, randomized trials

Authors: Flavio Giuseppe Biccirè, Nieves Gonzalo, Joo-Yong Hahn, Ik-Kyung Jang, Lorenz Räber

Lorenz Räber

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