Michael Honigberg: Clonal Hematopoiesis as a Driver of Aortic Valve Calcification
Michael Honigberg, Associate Professor of Medicine at Harvard Medical School, Associate Editor at Journal of the American College of Cardiology (JACC), shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Cardiovascular Medicine, adding:
“Excited to share our new preprint – a highly collaborative effort integrating population genomics, cardiac imaging, and experimental biology, led by Aeron Small with the Trevor Fidler and Elena Aikawa labs.
We found that ASXL1-mutant clonal hematopoiesis (CHIP) was associated with incident aortic stenosis and worse aortic valve hemodynamics.
In complementary experiments, ASXL1-mutant macrophage-like cells produced a pro-inflammatory secretome and accelerated calcification in human valve cells, a response blunted by IL-1 or IL-6 inhibition.
Grateful to co-authors and collaborators including Liying Xue, Shinsuke Ito, Cesar De Jeronimo, Sasha A. Singh, Mesbah Uddin, Art Schuermans, Spencer Flynn, George Thanassoulis, Peter Libby, Amil Shah, Christie Ballantyne, Pradeep Natarajan.”
Title: ASXL1-Mutant Clonal Hematopoiesis is Associated with Calcific Aortic Valve Disease and Promotes Valvular Calcification In Vitro
Authors: Aeron Small, Liying Xue, Shinsuke Ito, Cesar De Jeronimo Diaz, Yuto Nakamura, Niekbachsh Mohammadnia, Huajun Liao, Yota Maekawa, Linke Li, Sasha A Singh, Taku Kasai, Luisa Weiss, Md Mesbah Uddin, Art Schuermans, Spencer Flynn, Elby Mackenzie, James C Engert, George Thanassoulis, Peter Libby, Amil Shah, Christie M. Ballantyne, Pradeep Natarajan, Trevor Fidler, Elena Aikawa, Michael C. Honigberg
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