Dianne E. van der Wal: C-Terminal Endings Impact PAR1/PAR4 Peptide Potency in In Vitro Platelet Assays
Dianne E. van der Wal, Honorary Lecturer at the University of Sydney, Researcher at the ANZAC Research Institute, and Editor at Platelets journal, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in JTH, adding:
“Now in Journal of Thrombosis and Haemostasis (JTH)
When stimulating your platelets’ thrombin receptors in vitro, please be aware of the C-terminal ending of the PAR1/PAR4 peptides used
Their potency is very different in flow cytometry and light transmission aggregation assays.
Sofia Ramström Marie Lordkipanidze Imane B.
New International Society on Thrombosis and Haemostasis (ISTH) SSC paper.”
Title: Impact of C-terminal amidation on platelet activation by PAR1 and PAR4 activating peptides: Communication from the ISTH SSC Subcommittee on Platelets in Health and Disease
Authors: Imane Boukhatem, Jessica Blais, Dianne E. van der Wal, Hanna Baloch, Tea Jerlström, Marie Lordkipanidzé, Sofia Ramström
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