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A Plasma Proteomic Signature of Antiphospholipid Syndrome – JTH
JTH/LinkedIn
Oct 7, 2026, 13:49

A Plasma Proteomic Signature of Antiphospholipid Syndrome – JTH

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Dagmar van Mourik et al, adding:

“Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome.

The study used two cohorts: a discovery cohort (61 APS patients versus 19 controls) and a verification cohort (77 versus 49).

Quantitative mass spectrometry of 159 plasma proteins found six proteins that differed consistently in clinically stable APS: alpha-1-acid glycoprotein 1, β2-microglobulin, complement C2, IGFALS, LRG1 and cystatin-C.

The authors suggest these point to subclinical inflammation and renal involvement.”

Title: Plasma protein profile in patients with antiphospholipid syndrome and controls without antiphospholipid syndrome

Authors: Dagmar J.M. van Mourik, Britte F. van der Vliet, Dorien Salet, L. Renee Ruhaak, Natasja Dolezal, Jan Wouter Drijfhout, Robert A. Cordfunke, Astrid van Hylckama Vlieg, Frederikus A. Klok, Michiel Coppens, Mettine H.A. Bos, Saskia Middeldorp, Jeroen C.J. Eikenboom, Bart J.M. van Vlijmen, Thijs E. van Mens

A Plasma Proteomic Signature of Antiphospholipid Syndrome - JTH

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Antiphospholipid Syndrome APS Astrid van Hylckama Vlieg Bart J.M. van Vlijmen Britte F. van der Vliet cystatin C Dorien Salet Frederikus A Klok Health Hematology Hemostasis Hemostasis News Hemostasis Today Jan Wouter Drijfhout Jeroen C.J. Eikenboom Journal of Thrombosis and Haemostasis JTH L. Renee Ruhaak Medicine Mettine H.A. Bos Michiel Coppens Natasja Dolezal Robert A. Cordfunke Saskia Middeldorp Thijs E. van Mens β2-microglobulin
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