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Backflow-Induced Clot Formation During Red Cell Transfusion – AABB

AABB/LinkedIn

Nov 3, 2026, 13:06

Backflow-Induced Clot Formation During Red Cell Transfusion – AABB

AABB shared a post on LinkedIn about a recent article by Vandela Brismar et al., published in Journal Transfusion, adding:

“A red cell unit arrived with clots the size of a fist. Twelve hours later, when it was photographed, fibrinolysis had dissolved much of the evidence. So what happened?

A new, subscriber-only case report from Karolinska Universitetssjukhuset in Stockholm details the investigation.

Records showed no deviations in blood donation, component manufacturing, transportation or storage.

Serological testing provided the key clue: the donor and patient differed in two antigens, c and Jka, and testing revealed evidence of both patient and donor blood in the transfusion set and blood bag.

The findings indicated backflow of patient blood into the red cell unit, likely through the transfusion set. Transportation during an active transfusion was suspected as a contributing factor, though the precise cause was not confirmed.”

Title: Backflow of patient blood during transfusion causing clotting

Authors: Vendela Brismar, Daniel Wessman, Stella Larsson

Backflow-Induced Clot Formation During Red Cell Transfusion - AABB