Dino Mehic: Targeting TFPI in Unexplained Bleeding Disorders
Dino Mehic, Physician Scientist at Medical University of Vienna, shared a post on LinkedIn about recent articles he and his colleagues co-authored, adding:
“Could targeting the tissue factor–TFPI pathway offer a new therapeutic approach for patients with bleeding disorder of unknown cause (BDUC)?
In our recent commentary in the Journal of Thrombosis and Haemostasis (JTH), co-authored with Alisa Wolberg, we discuss the findings of Monzón Manzano et al., who demonstrated impaired tissue factor–dependent thrombin generation in a subgroup of patients with BDUC, which could be restored in vitro using concizumab or rFVIIa.
These findings provide new insights into the pathophysiology of BDUC and open potential avenues for targeted therapies.”
Title 1: Bypassing bleeding disorder of unknown cause?
Authors: Dino Mehic, Alisa S. Wolberg
Read the Full Article on JTH
Title: The tissue factor-TFPI pathway as a therapeutic target in bleeding disorders of unknown cause
Authors: Elena Monzón Manzano, Paula Acuña, Mónica Martín Salces, María Isabel Rivas Pollmar, Eduardo García Pérez, José Manuel Martín de Bustamante González-Iglesias, Mar Gutiérrez, Víctor Jiménez Yuste, Nora Butta, María Teresa Álvarez Román
Read the Full Article on JTH
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