Bahar Artım Esen: Rituximab in Antiphospholipid Syndrome
Bahar Artım Esen, Professor at Istanbul University Faculty of Medicine, shared a post on LinkedIn about a recent article, she and her colleagues co-authored, published in Rheumatology Journal, adding:
“Falling antibody titres are easily mistaken for falling risk.
Our long-term study of rituximab in antiphospholipid syndrome, now published in RheumJnl, shows why that assumption deserves scrutiny.
The serological response was real but short-lived, and it did not predict who would go on to have recurrent thrombosis.
Most recurrences occurred where anticoagulation had lapsed or fallen below target.
The implication is practical. Rituximab may help selected patients with refractory disease, but it does not replace anticoagulation, which remains the foundation of thrombosis prevention. A laboratory response is not a clinical outcome and should not be managed as one.
Many thanks and congratulations to Omer Uludag for leading this work, and to all our co-authors.”
Title: Serological and clinical outcomes of rituximab in APS with or without SLE: a retrospective single-centre cohort
Authors: Ömer Uludağ, Gamze Kemec, Soner Altın, Burak İnce, Yasemin Yalçınkaya, Sevil Kamalı, Ahmet Gül, Murat Inanç, Bahar Artim-Esen
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