Sally Mandour: Ringed Sideroblasts in Peripheral Blood
Sally Mandour, Associate Professor, Head of Hematology Unit at Clinical Pathology Department of National Liver Institute, Monofeya University, shared a post on LinkedIn:
”Ringed sideroblasts in peripheral blood!
Ring sideroblasts are erythroblasts with iron-loaded mitochondria visualized only by Prussian blue staining (Perls’ reaction) as a perinuclear ring of blue granules it’s interesting to know that, in very rare conditions you can spot them transiently even in peripheral blood !
Giemsa staining of peripheral blood smears (panels A-C, original magnification ×1000) demonstrated numerous nucleated red blood cells (54/100 white blood cells) with 27 percent ring sideroblasts (red arrow). Numerous inclusions (Pappenheimer bodies, blue arrow) were also present in the erythrocytes.
Prussian blue staining confirmed the inclusions were iron positive (panels D-F, original magnification times 1000).
This is a case of hemolytic anaemia showed normoblastaemia and RBCs inclusions which were confirmed as ringed sideroblasts and iron granules (papenhiemer bodies) on Perls’ staining.”
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