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Ney Carter Borges: Cholesterol-Inflammation Fusion in Atherosclerosis
Ney Carter Borges/LinkedIn
Mar 5, 2026, 15:35

Ney Carter Borges: Cholesterol-Inflammation Fusion in Atherosclerosis

Ney Carter Borges, Member Cardiologist of Global Physician Association at Cleveland Clinic Florida, shared a post on LinkedIn:

“Cholesterol–Inflammation Fusion in Atherosclerosis

Key mechanistic pathway

1. LDL infiltration

Circulating LDL penetrates the vascular intima and undergoes oxidative modification forming oxidized LDL (ox-LDL).

2. Macrophage lipid uptake

ox-LDL binds scavenger receptors (e.g., CD36) leading to macrophage lipid accumulation and foam-cell formation.

3. Cholesterol crystal formation

Excess intracellular cholesterol crystallizes, causing lysosomal rupture and activation of the NLRP3 inflammasome.

4. Inflammatory cascade

Inflammasome activation promotes IL-1β, IL-6 and TNF-α release, amplifying vascular inflammation.

5. Disruption of cholesterol efflux

Cytokines suppress ABCA1 and ABCG1 transporters, impairing HDL-mediated cholesterol removal.

6. Self-perpetuating loop

Reduced cholesterol efflux increases lipid accumulation, further activating inflammatory pathways and accelerating plaque progression.

This bidirectional cycle between lipid dysregulation and vascular inflammation constitutes the cholesterol-inflammation fusion loop, a key mechanism driving plaque progression and instability in atherosclerotic cardiovascular disease.”

Ney Carter Borges: Cholesterol-Inflammation Fusion in Atherosclerosis

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(inflammation Atherosclerosis bleeding disorders Cholesterol Health Hematology Hemostasis News Hemostasis Today Medicine Ney Carter Borges
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