Ney Carter Borges: Cholesterol-Inflammation Fusion in Atherosclerosis
Ney Carter Borges, Member Cardiologist of Global Physician Association at Cleveland Clinic Florida, shared a post on LinkedIn:
“Cholesterol–Inflammation Fusion in Atherosclerosis
Key mechanistic pathway
1. LDL infiltration
Circulating LDL penetrates the vascular intima and undergoes oxidative modification forming oxidized LDL (ox-LDL).
2. Macrophage lipid uptake
ox-LDL binds scavenger receptors (e.g., CD36) leading to macrophage lipid accumulation and foam-cell formation.
3. Cholesterol crystal formation
Excess intracellular cholesterol crystallizes, causing lysosomal rupture and activation of the NLRP3 inflammasome.
4. Inflammatory cascade
Inflammasome activation promotes IL-1β, IL-6 and TNF-α release, amplifying vascular inflammation.
5. Disruption of cholesterol efflux
Cytokines suppress ABCA1 and ABCG1 transporters, impairing HDL-mediated cholesterol removal.
6. Self-perpetuating loop
Reduced cholesterol efflux increases lipid accumulation, further activating inflammatory pathways and accelerating plaque progression.
This bidirectional cycle between lipid dysregulation and vascular inflammation constitutes the cholesterol-inflammation fusion loop, a key mechanism driving plaque progression and instability in atherosclerotic cardiovascular disease.”
Other posts featuring Ney Carter Borges on Hemostasis Today.
-
Apr 15, 2026, 08:51Moustafa Abdou: Sutimlimab is Transforming Outcomes in Cold Agglutinin Disease
-
Apr 15, 2026, 04:52Ulrich Pecks: Personalized Approaches to VTE Prevention in Pregnant Women with Inherited Thrombophilia
-
Apr 15, 2026, 04:06Brenda Pleasant: Insights from the HFA Symposium on Hemophilia Care
-
Apr 15, 2026, 03:43Lexy Halloran: Addressing Diagnostic Inequities in Women with Chronic Conditions
-
Apr 14, 2026, 17:32Denise M.: Surviving Sepsis 2026 – The Upstream Revolution
-
Apr 14, 2026, 17:23Meghanath Yenni։ What’s New in Acute Ischemic Stroke in 2026
-
Apr 14, 2026, 17:11Phil Spinella: What Dose of TXA for Children With Severe Traumatic Bleeding Should You Use?
-
Apr 14, 2026, 17:08Abdulrahman Katib: How Endovascular Stenting Is Transforming the Treatment of Severe PTS
-
Apr 14, 2026, 17:00Anna A. Avagyan: Glad to Be Part of EHA Pediatric Hematology-Oncology Course