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Omar Adwan Explains the Key Difference Between Serum and Plasma
Sep 8, 2025, 07:03

Omar Adwan Explains the Key Difference Between Serum and Plasma

Omar Adwan, Medical Laboratory Technologist of Modawah lab center, shared a post on LinkedIn:

“Difference Between Serum and Plasma

Plasma

  • Plasma is the liquid portion of blood obtained by collecting the sample in tubes containing anticoagulants such as EDTA, Heparin, or Citrate, followed by centrifugation.
  • Contains fibrinogen (a clotting protein)
  • Commonly used for tests such as CBC, PT, APTT, coagulation studies, and D-dimer
  • Derived from blood that has not clotted

Serum

  • Serum is the liquid portion of blood obtained after clot formation, using tubes without anticoagulants such as the plain red-top tube or the gold-top serum separator tube (SST), then centrifuged.
  • Does not contain fibrinogen (consumed during clotting process)
  • Commonly used for tests such as blood chemistry, hormone assays, antibody detection, and immunological studies
  • Derived from blood that has been allowed to clot before centrifugation

Summary

  • Plasma → collected in tubes with anticoagulants; Serum → collected in tubes without anticoagulants
  • Plasma contains fibrinogen, whereas Serum does not contain fibrinogen”

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