Sifat Jubaira: When Low MCV Meets High Platelets
Sifat Jubaira, Lab Medicine Specialist at United Hospital Limited, shared a post on LinkedIn:
”High Platelets (typically quote 450,000/µL) plus Low MCV – Think Iron Deficiency Anemia.
Seen in 30 percent cases of IDA.
Quick CBC pearl:
- Low MCV equals microcytic, smaller RBCs
- High platelets equals reactive thrombocytosis
Why does it happen?
Iron deficiency or chronic blood loss stimulates the bone marrow. Since RBCs and platelets share precursor pathways, platelet production may rise while RBCs become smaller.
Clinical importance:
This pattern strongly supports iron deficiency anemia and helps differentiate it from many other anemias that do not typically present with both microcytosis plus thrombocytosis.
Important differential:
- Reactive (secondary) thrombocytosis – iron deficiency, infection, inflammation
- Primary (clonal) thrombocythemia – myeloproliferative disorders (e.g., JAK2 mutation)
Memory hook: Low MCV plus High Platelets, Think Iron Deficiency First.
References:
- Source: Williams Hematology and Harrison’s Principles of Internal Medicine.
- Key Concept: ‘Reactive Thrombocytosis in Iron Deficiency Anemia.’ – Dr. Sifat Jubaira MBBS, MPhil, MPH”
Find more posts featuring Sifat Jubaira on Hemostasis Today.
-
Jun 24, 2026, 17:04Recurrent Cervical Internal Carotid Vasospasm Linked to Autosomal Recessive PTGIS Defect – International Journal of Stroke
-
Jun 24, 2026, 16:49Gaurav Kharya: Bridging the Gap in Safe Blood Access for Patients Who Can’t Wait
-
Jun 24, 2026, 16:40William Wallace: Vitamin C and Collagen Work as One Biological System
-
Jun 24, 2026, 16:32Arlindo Nascimento de Lemos Junior: Thrombus Echogenicity as a Predictor of Post-Thrombotic Syndrome Severity After DVT
-
Jun 24, 2026, 16:09Jimi Olaghere: The Future of Sickle Cell Disease Research Starts With Collaboration
-
Jun 24, 2026, 16:03Von Willebrand Disease as a Common Yet Under-Recognised Bleeding Disorder – EHC
-
Jun 24, 2026, 15:57Maia Meier: Women with Bleeding Disorders Reach the Summit of Mont Blanc
-
Jun 24, 2026, 15:40Annette Bowyer: The Emerging Role of Extravascular Factor VII in Haemostasis
-
Jun 24, 2026, 13:50Tijjani Balas: Why Early Detection of DVT Matters