Surbhi Singh: Platelet Clumps — The Culprit Behind Pseudothrombocytopenia
Surbhi Singh, Consultant Haematopathology at Agilus Diagnostics and Fortis Hospital Gurugram, shared a post on LinkedIn:
“Cellfie Of The Day
*Platelet Clumps — The Culprit Behind Pseudothrombocytopenia
*What you see:
Large platelet aggregates on the peripheral smear, often at the feathered edge or around neutrophils/monocytes.
*Why it matters:
These clumps falsely lower automated platelet counts, leading to pseudothrombocytopenia — a lab artefact, not a true thrombocytopenia.
*Mechanism:
• Most commonly EDTA-dependent platelet agglutination.
• Autoantibodies targeting GP IIb/IIIa become activated in EDTA, causing platelets to clump in vitro.
*Clues on smear:
• Platelet clumps at the tail end.
• Adequate giant platelets or normal platelet morphology.
• Normal RBC and WBC morphology unless concurrent pathology.
*What to do:
• Repeat CBC in citrate anticoagulant.
• Manual smear review to confirm.
• Report corrected platelet count from alternative tube if clumping resolves.”
Stay informed with Hemostasis Today.
-
Aug 31, 2026, 05:35Does LDL Cholesterol Influence VTE Risk? – Ordo Fraterna Fibonacci
-
Aug 31, 2026, 05:19Tania Ahuja: Apixaban in Abdominal Transplant Patients
-
Aug 31, 2026, 04:28Reza Hafidz Irawan։ Automated Antibody Titration With Erytra Eflexis
-
Aug 31, 2026, 04:17Safa Chenganath: Stenosis vs Thrombosis – Hemodialysis Vascular Access
-
Aug 30, 2026, 17:13J. Meireles-Brandao: Hypertension, Inflammation and Lipoprotein Disease
-
Aug 30, 2026, 17:10Hugh Nguyen: Leading the New Era of Blood Services Across Asia Pacific
-
Aug 30, 2026, 17:09Transforming Childhood Through Access to Hemophilia Treatment – World Federation of Hemophilia
-
Aug 30, 2026, 17:07Raj Bharath: Connecting Clinicians and Researchers to Advance Transfusion Medicine
-
Aug 30, 2026, 17:04Rana Al Hrout: Free FRCPath Haematology Part 1 Exam Preparation Session