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Tareq Abadl: The Critical Role of ADAMTS13 Activity Testing in Diagnosing TTP
Tareq Abadl/LinkedIn
Feb 12, 2026, 14:12

Tareq Abadl: The Critical Role of ADAMTS13 Activity Testing in Diagnosing TTP

Tareq Abadl, Medical Laboratory Specialist and Director of the Blood Bank at Dr. Abdelkader Al-Mutawakkil Hospital, shared a post on LinkedIn:

“ADAMTS13 Activity Test

What is it?

A laboratory test that measures the activity of the enzyme ADAMTS13, which cleaves ultra-large von Willebrand factor (vWF) multimers into smaller, less thrombogenic fragments.

What does it detect?

Primarily used to diagnose:

  •  Thrombotic Thrombocytopenic Purpura (TTP)

A rare but life-threatening thrombotic microangiopathy characterized by:

  1. Severe thrombocytopenia
  2. Microangiopathic hemolytic anemia
  3. Neurologic symptoms
  4. Renal dysfunction
  5. Fever

Normal Reference Range:

ADAMTS13 activity: ~50–150%
(May vary slightly depending on the laboratory and assay method)

Key Diagnostic Point:

Low ADAMTS13 activity less than 10% – Strongly diagnostic of TTP

The deficiency may be:

  1. Immune-mediated (autoantibodies against ADAMTS13)
  2. Congenital (hereditary deficiency)

Why is this test critical?

  1. TTP is not diagnosed by routine coagulation tests
  2. Delayed diagnosis can be fatal
  3. Plasma exchange (PLEX) must be started immediately when TTP is suspected.

Think TTP if you see:

  1. Decreased Platelets
  2. Elevated LDH
  3. Decreased Haptoglobin
  4. Normal PT / aPTT

Suspect TTP and order ADAMTS13 activity urgently.”

Tareq Abadl: The Critical Role of ADAMTS13 Activity Testing in Diagnosing TTP

Find more posts featuring Tareq Abadl on Hemostasis Today.

ADAMTS13 ADAMTS13 Activity Test ADAMTS13 deficiency Health Hematology Hemostasis Hemostasis Today Immune Thrombotic Thrombocytopenic Purpura Medicine microangiopathic hemolytic anemia Renal dysfunction Tareq Abadl thrombosis
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