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Thirunavukkarasu Angappan: The Geopolitics of Plasma Supply and Self-Sufficiency
Thirunavukkarasu Angappan/LinkedIn
Jul 10, 2026, 15:11

Thirunavukkarasu Angappan: The Geopolitics of Plasma Supply and Self-Sufficiency

Thirunavukkarasu Angappan, Vice President of Operations and Manufacturing at PopVax, shared a post on LinkedIn:

“The World Runs on American Plasma — And That’s Dangerous.

One country supplies most of the world’s source plasma.

That creates a global healthcare vulnerability few policymakers discuss openly.

Today, the United States contributes approximately 70 percent of global source plasma supply.

That dominance is driven by:

  • compensated donor systems
  • high-frequency donation models
  • massive collection infrastructure
  • vertically integrated plasma networks

But this concentration creates systemic risk.

During COVID-19:

  • US plasma donations dropped sharply
  • Global immunoglobulin shortages followed
  • Hospitals across multiple regions faced treatment constraints
  • Europe still depends heavily on imported plasma.

Meanwhile:

  • global IVIG demand continues growing 6–8 percent annually
  • neurological indications are expanding rapidly
  • fractionation capacity remains constrained

The uncomfortable reality:

The global plasma economy has a single critical dependency.

And dependencies eventually become geopolitical issues.

Countries are now responding:

  • UK rebuilding domestic plasma capabilities
  • Malaysia expanding regional partnerships
  • Europe debating self-sufficiency strategies
  • China investing aggressively in biologics independence

The question is no longer whether diversification is needed.

The question is whether it is already too late to avoid future supply instability.

Should Europe and Asia adopt compensated plasma donation models to improve self-sufficiency — or would that undermine the ethical foundations of voluntary donation systems?”

Thirunavukkarasu Angappan: The Geopolitics of Plasma Supply and Self-Sufficiency

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