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Intra-Arterial Tenecteplase After Thrombectomy: Promising but Inconclusive
Jul 5, 2025, 17:43

Intra-Arterial Tenecteplase After Thrombectomy: Promising but Inconclusive

Ashutosh Jadhav recently shared a post on further management of stroke after successful thrombectomy on X:

”Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy.”

Read the full JAMA article here.

A recent study evaluating intra-arterial tenecteplase administered after successful thrombectomy in patients with acute large vessel occlusion (LVO) presenting between 4.5 and 24 hours of symptom onset has shown encouraging yet inconclusive results.

Patients receiving intra-arterial tenecteplase demonstrated a greater likelihood of excellent neurological outcomes at 90 days, without an associated increase in symptomatic intracranial hemorrhage (sICH) or mortality.

However, the optimism was tempered by the fact that none of the secondary efficacy endpoints reinforced the primary findings.

The authors emphasized that further trials are necessary to validate these results and better define the role of intra-arterial tenecteplase in extended-window stroke management.

Thrombectomy

More on advancements in stroke management featured in Hemostasis Today.

Ashutosh Jadhav Health Hematology Hemostasis Today JAMA Medicine stroke Tenecteplase Thrombectomy
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