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Tiago Lopes: Can AI Predict Immune Reactions of New Drugs? Yes!
Tiago Lopes/LinkedIn
Feb 3, 2026, 10:05

Tiago Lopes: Can AI Predict Immune Reactions of New Drugs? Yes!

Tiago Lopes, Research Scientist at Heidelberg University, shared on LinkedIn:

”Can AI predict immune reactions of new drugs? Yes.

Its not perfect, but it is very good.

In this paper fresh from the oven, my colleagues from Japan and I present a new coagulation factor 8 (FVIII), designed and tested as a gene therapy.

People who have a defect in this gene live with hemophilia, a coagulation problem that requires constant injections; and even then, they are at constant risk of joint, muscle and other hemorrhages.

The treatment is super expensive, and still has a major problem of triggering an immune reaction; it renders the treatment ineffective, which without a doubt, sucks.

Here, a comprehensive and reliable AI prediction was made, showing this FVIII variant is not worse than the “original” protein that people have.

Hope. This is the word for patients and their families.

We are working around the clock to have your kids playing soccer without worrying about not walking the next day.”

Tiago Lopes: Can AI Predict Immune Reactions of New Drugs? Yes!

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