Wolfgang Miesbach Reports Promising Results for New Subcutaneous von Willebrand Disease Therapy VGA039
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn:
“Promising results in new subcutaneous von Willebrand disease treatment presented at BIC 2025!
Carolyn Miller presented Phase I results for VGA039:
This monoclonal antibody targets Protein S to restore balance in blood clotting by inhibiting both tissue factor pathway inhibitor α (TFPIα) and activated protein C (aPC), enhancing thrombin generation during both initiation and propagation phases of coagulation.
The VIVID 2 study enrolled 10 VWD patients (ages 21-52) with diverse VWD subtypes, including those with mild hemophilia A. Results showed increased thrombin generation lasting 4+ weeks without dose-limiting toxicities:
Safe and well-tolerated across all VWD types (1, 2A, 2M, 2N, 3)
- Single subcutaneous injection maintained therapeutic concentrations for ~4 weeks
- Significant bleed reduction: 75-88% reduction in annualized bleeding rates in high-bleed patients
- Universal approach: Works across all VWD types by targeting Protein S
Unlike current VWD treatments requiring multiple weekly IV infusions, VGA039 may offer convenient subcutaneous dosing with sustained multi-week protection.”
More recent insights on Hemostasis Today.
-
Apr 11, 2026, 13:51David McIntosh: Vital Plasma Derived Medicines – The Anomalous UK Scene
-
Apr 11, 2026, 13:47Samrawit Terefe: O Negative Blood Is the Universal Donor With Extreme Scarcity
-
Apr 11, 2026, 13:39Dheeraj Garg: Rethinking Cardiovascular Disease – A Cardiologist’s Perspective
-
Apr 11, 2026, 13:37Kushal Bhatia: Is The 4.5-Hour Thrombolysis Window Officially Outdated?
-
Apr 11, 2026, 13:35William Aird: Why Did Mammalian Red Blood Cells Give Up Their Nucleus?
-
Apr 11, 2026, 13:30Ken Kuang: Gravity Is Constant, But Your Vein Health Doesn’t Have to Be
-
Apr 11, 2026, 13:21Mascha Kern: Measuring Gender’s Role in Stroke and Migraine
-
Apr 11, 2026, 13:10Danique Steeghs: Key Findings from a Microfluidic Chemiluminescent Thrombin Generation Assay
-
Apr 11, 2026, 13:06Shanvi Mahi: A Validated Tool to Explore Lived Experiences After Stroke Rehabilitation