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Ahmed Nasreldein: Minor Ischemic Stroke Often Puts Clinicians at a Crossroads
Ahmed Nasreldein/LinkedIn
Dec 28, 2025, 14:26

Ahmed Nasreldein: Minor Ischemic Stroke Often Puts Clinicians at a Crossroads

Ahmed Nasreldein, Professor of Neurology at Assiut University, reposted from Matteo Foschi on LinkedIn:

”Minor ischemic stroke often puts clinicians at a crossroads: immediate reperfusion therapy or optimized medical treatment with dual antiplatelets and statins?

This new experts guidance tackles that dilemma: to intervene or not.

Proud to be part of the incredible team behind it.”

Quoting Matteo Foschi‘s post:

”Thrilled to share our new Expert Guidance on the acute management of minor ischemic stroke!

Honored to have co-led this work with an outstanding international team of stroke leaders, now published in Stroke (American Heart Association).

Federico De Santis, Lucio D’Anna, Urs Fischer, Else Charlotte Sandset, Thanh Nguyen, Ahmed Nasreldein, Octavio Marques Pontes-Neto, Tsivgoulis Georgios, Pooja Khatri, Shelagh Coutts, Guillaume Turc, Simona Sacco

Minor ischemic strokes may appear “mild,” but up to 30% of patients develop disability within 90 days — a reminder that minor does not mean benign.

Our guidance provides a pragmatic, scenario-based framework to support clinicians in navigating some of the most controversial areas in acute stroke care:

  • Disabling vs nondisabling minor stroke
  • Role of IV thrombolysis and dual antiplatelet therapy
  • Early anticoagulation in cardioembolic minor stroke
  • When (and whether) to perform thrombectomy in low NIHSS with LVO
  • Managing rapidly improving symptoms
  • Post-reperfusion antithrombotic strategies
  • Considerations for low-resource settings

This document aims to translate complex evidence into clear, actionable decision pathways, highlighting where we do have robust data — and where future trials are urgently needed.

A huge thank you to all coauthors and collaborators worldwide for their expertise, energy, and commitment

Open access article available now.

Proud to contribute to improving global stroke care and to stimulate the next generation of research in this challenging field.”

Read the full article here.

Article: Acute Treatment of Disabling and Nondisabling Minor Ischemic Stroke: Expert Guidance for Clinicians

Authors: Federico De Santis, Matteo Foschi, Pooja Khatri, Ahmed Nasreldein, Else Charlotte Sandset, Georgios Tsivgoulis, Lucio D’Anna, Shelagh B. Coutts, Urs Fischer, Octávio Marques Pontes-Neto, Thanh N. Nguyen, Guillaume Turc, Simona Sacco

Ahmed Nasreldein: Minor Ischemic Stroke Often Puts Clinicians at a Crossroads

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Ahmed Nasreldein American Heart Association Antiplatelets Health Hematology Hemostasis Hemostasis Today Ischemic stroke LVO Matteo Foschi Medicine statins Thrombolysis thrombosis
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