Decoding the Inflammatory–Metabolic Axis in Atherosclerosis: A New Frontier in Cardiovascular Prevention- by Atherosclerosis
Atherosclerosis published on X:
“Metabolic, renal, and inflammatory crosstalk in atherosclerotic cardiovascular disease: Evolving landscape and future directions.”
Title: Metabolic, renal, and inflammatory crosstalk in atherosclerotic cardiovascular disease: Evolving landscape and future directions.
Authors: Harris Avgousti, Matthew J. Feinstein
This recent publication in Atherosclerosis explores the complex interplay between metabolic dysfunction, renal impairment, and systemic inflammation in driving atherosclerotic cardiovascular disease (ASCVD). The review highlights how shared molecular pathways—such as oxidative stress, cytokine cascades, and metabolic-renal feedback loops—converge to accelerate plaque progression and vascular injury.
The authors emphasize a paradigm shift toward integrated, multi-system prevention strategies, including anti-inflammatory therapies, metabolic modulation, and kidney function preservation. This evolving understanding holds promise for personalized ASCVD management and novel therapeutic targets.
Read the abstract: Atherosclerosis Journal (June 2025).
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