Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
February, 2026
February 2026
M T W T F S S
 1
2345678
9101112131415
16171819202122
232425262728  
Recombinant ADAMTS13 Shows Superior Efficacy Over Plasma in Congenital TTP: A Paradigm Shift in Replacement Therapy – Blood Journals Portfolio
Blood Journals Portfolio/X
Jun 17, 2025, 05:10

Recombinant ADAMTS13 Shows Superior Efficacy Over Plasma in Congenital TTP: A Paradigm Shift in Replacement Therapy – Blood Journals Portfolio

A recent study published by Blood Journals Portfolio (May 2024) available here demonstrates that recombinant ADAMTS13 (rADAMTS13) offers significantly more efficient ADAMTS13 replacement than traditional plasma infusions in patients with congenital thrombotic thrombocytopenic purpura (cTTP).

This finding marks a critical step forward in targeted therapy for patients with severe ADAMTS13 deficiency, a condition that leads to life-threatening microangiopathic hemolytic anemia and thrombocytopenia. Unlike plasma, which delivers ADAMTS13 in variable and limited concentrations, recombinant formulations offer predictable pharmacokinetics, higher bioavailability, and eliminate the risks associated with plasma-derived products, including allergic reactions and pathogen transmission.

These results underscore the potential of rADAMTS13 to become the standard of care in managing cTTP, improving prophylactic and acute-phase treatment outcomes.

Blood Journals Portfolio shared on X:

“Recombinant ADAMTS13 can supply ADAMTS13 more efficiently than plasma to patients with congenital thrombotic thrombocytopenic purpura.”

Title: Therapeutic switch from plasma to recombinant ADAMTS13 for patients with congenital TTP from Japanese real-world data

Autors: Kazuya Sakai, Atsushi Hamamura, Yoshiko Yoshimura, Miyuki Abe, Yoshiyuki Ogawa, Kazuki Tanaka, Norimichi Hattori, Tazuko Tokugawa, Rie Kanai, Fumiyoshi Ikejiri, Masahiro Takeyama, Teruhisa Taoka, Naoki Fujita, Minoru Kanaya, Katsuyoshi Koh, Hiroshi Shiragami, Hidekazu Azumi, Kenki Saito, Masanori Matsumoto

Blood Journals Portfolio

See more in-depth professional insights at Hemostasis Today, where we bring you the latest advances in thrombosis, hemostasis, and rare bleeding disorders.

ADAMTS13 deficiency ASH Atsushi Hamamura Blood Global Hematology Congenital TTP Congenital TTP (cTTP) Fumiyoshi Ikejiri Hematology Hemostasis Hemostasis innovation Hemostasis Today Hidekazu Azumi Hiroshi Shiragami International Society on Thrombosis and Haemostasis (ISTH) Katsuyoshi Koh Kazuki Tanaka Kazuya Sakai Kenki Saito latest advances in thrombosis Masahiro Takeyama Masanori Matsumoto Microangiopathy Minoru Kanaya Miyuki Abe Naoki Fujita Next-generation hemostatic treatment Norimichi Hattori Plasma replacement therapy Rare Bleeding Disorders Recombinant ADAMTS13 Rie Kanai Tazuko Tokugawa Teruhisa Taoka Thrombotic microangiopathies (TMA) Thrombotic thrombocytopenic purpura TTP Yoshiko Yoshimura Yoshiyuki Ogawa
NewsFeed