Ewa Fiorentino Rozek: APS – When “Unprovoked” Clots And Pregnancy Loss Connect
Ewa Fiorentino Rozek, Head of Clinical Affairs at AliveDx, shared on LinkedIn:
‘‘Antiphospholipid Syndrome (APS): when “unprovoked” clots and pregnancy loss connect
What it is: An autoimmune pro-thrombotic state causing venous/arterial thromboses and pregnancy morbidity.
It can be primary or overlap with SLE.
Patients often appear “too young” for DVT/PE or stroke; recurrent miscarriage may be the first clue.
Clinical clues: unprovoked DVT/PE, stroke/TIA under 50, livedo reticularis, thrombocytopenia, recurrent early losses or late complications in pregnancy.
Management changes dramatically if APS is confirmed—anticoagulation choices and obstetric planning differ.
Diagnostics (snapshot):
– Antibodies: anticardiolipin (aCL) and anti-β2GPI (IgG/IgM).
– Functional: lupus anticoagulant (LA).
– Key principle: persistence—positive results repeated after ~12 weeks to confirm.”
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