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Francesca Palandri: Is There Still a Place for Splenectomy in ITP in the Modern Era?
Francesca Palandri/LinkedIn
Sep 24, 2026, 12:34

Francesca Palandri: Is There Still a Place for Splenectomy in ITP in the Modern Era?

Francesca Palandri, Hematologist at IRCCS Sant’Orsola Polyclinic – Bologna University Hospital, shared a post on LinkedIn:

“Is there still a place for splenectomy in ITP in the modern era?

With TPO-RAs and rituximab available, splenectomy is often seen as a thing of the past.

In the GIMEMA ITP1324 study, we analyzed a multicentre cohort of 97 adults with ITP who had a splenectomy between 2010 and 2022.

Our data were presented at SIE – Italian Society of Hematology and suggest the answer is yes:

  • Still effective: 59–69% overall response in the first 6 months (CR up to 65%), despite use after >4 lines of medical therapy.
  • A safe procedure with modern prophylaxis: 94% of patients were vaccinated, prior rituximab and the surgical approach did not change response or complications.
  • Choosing patients matters: patients ≥60 years responded less often and needed further treatment almost twice as often (62% vs 37%).

Splenectomy is still a valid option in today’s ITP treatment pathway.”

Francesca Palandri: Is There Still a Place for Splenectomy in ITP in the Modern Era?

Other posts featuring Francesca Palandri on Hemostasis Today.

bleeding disorders Blood Francesca Palandri GIMEMA ITP1324 study Health Hematology Hemostasis Hemostasis News Hemostasis Today ITP Splenectomy TPO-RAs
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