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Fresh Frozen Facts Part 3: A Thoughtful Look at Plasma Transfusion by Dr. Caitlin Raymond
Caitlin Raymond / LinkedIn
Jul 30, 2025, 12:34

Fresh Frozen Facts Part 3: A Thoughtful Look at Plasma Transfusion by Dr. Caitlin Raymond

Caitlin Raymond, MD/PhD shared an insightful chain of posts on LinkedIn:

”Fresh Frozen Facts, Part III: What FFP Doesn’t Do and Alternatives
Plasma transfusion isn’t benign. And too often, it isn’t necessary.

In Part III of my four-part series on plasma products, I dive into one of the most common — and most misguided — uses in transfusion medicine: the reflexive ordering of FFP in moments of clinical uncertainty.

  • Mild INR elevation before a procedure?
  • Confusing coagulopathy in a bleeding patient?
  • A vague feeling that “we should do something”?

For years, that “something” has too often been FFP — despite evidence that it’s ineffective, high-risk, and rarely the right tool for the job. This post breaks down:

  • Why plasma won’t correct a mildly elevated INR
  • The truth about coagulopathy in liver disease
  • Why FFP is not a volume expander
  • Better alternatives: PCCs, cryo, vitamin K, platelets, and targeted factor concentrates

I also tackle the risks we often overlook: TRALI, TACO, allergic reactions, and the resource burden of thawing, typing, and administering plasma when it won’t help.

If you’ve ever wondered when not to transfuse — or how to avoid “just in case” medicine — this one’s for you.”

Read the full poste here.

Caitlin Raymond, MD/PhD, has launched an educational series on Fresh Frozen Plasma (FFP), now available on her journal blog.

Enjoy the third part and make sure you do not miss all the Fresh Frozen Facts!

Fresh Frozen Facts Part 3: A Thoughtful Look at Plasma Transfusion by Dr. Caitlin Raymond

Stay tuned for updates to the Fresh Frozen Facts series on Hemostasis Today.

Caitlin Raymond DIC FFP FFP Is Not a Vitamin Fresh Frozen Plasma Health Hematology Hemostasis Today Medicine Plasma Transfusion TACO TRALI Transfusion Medicine
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