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Abdul Mannan on CVT risk with CHC: It is Not One-Size-Fits-All!
Abdul Mannan/LinkedIn
Oct 2, 2025, 04:55

Abdul Mannan on CVT risk with CHC: It is Not One-Size-Fits-All!

Abdul Mannan, Consultant Haematologist at Betsi Cadwaladr University Health Board, shared on LinkedIn:

”CVT risk with CHC is not one-size-fits-all.

The type of progestin matters enormously (fourth-generation worst), and the multiplication of risk factors (family history, thrombophilia, obesity) creates scenarios with 200+ fold increased risk.

Most important clinical change:

  • Take family history more seriously – it predicts risk independently of thrombophilia testing.
  • And if you’re prescribing CHC, think twice about fourth-generation progestins.

The absolute risk remains low for most women, but for that high-risk subset (family history + thrombophilia), the numbers are sobering enough to have serious conversations about alternative contraception.”

Read the full article in JTH.

Article: The risk of cerebral vein thrombosis associated with different types of combined hormonal contraceptives: a case-control study

Authors: Maria Abbattista, Addolorata Truma, Ida Martinelli, Francesca Gianniello, Serena M. Passamonti, Marco Capecchi, Andrea Artoni, Flora Peyvandi, Paolo Bucciarelli

Abdul Mannan on CVT risk with CHC: It is Not One-Size-Fits-All!

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Abdul Mannan Addolorata Truma Andrea Artoni Flora Peyvandi Francesca Gianniello Health Hematology Hemostasis Hemostasis Today Ida Martinelli Marco Capecchi Maria Abbattista Medicine Paolo Bucciarelli Serena M. Passamonti thrombosis
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