Ala Altaie: We Found That Mononuclear Cells From RA Patients Can Trigger Clot Formation
Ala Altaie, Research Fellow in Mesenchymal Stem Cell Biology at the Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, shared a post on LinkedIn:
”New paper out!
Why do some patients on JAK inhibitors develop venous thromboembolism (VTE) or pulmonary embolism (PE) without deep vein thrombosis?
In our latest study led by Paula David and colleagues, we found that mononuclear cells from RA patients can trigger clot formation—especially when exposed to JAK inhibitors like tofacitinib.
This process, known as immunothrombosis, links the immune system to coagulation through increased Factor III production.
Panel A: Clots formed faster with tofacitinib
Panel B: Clot strength was higher
These findings shed light on the immune–coagulation connection behind JAK inhibitor–associated clots.
Read more.”
Title: Augmentation of immunothrombosis as a key mechanism underlying JAK inhibition associated hypercoagulability in rheumatoid arthritis
Authors: Paula David, Tom Macleod, Ala Altaie, Yu Shi, Kerem Abacar, Sami Giryes, Gabrielle de Mello Santos, Payal Ganguly, Mark Harland, Chi Wong, Andrew Scarsbrook, Paul Emery, Kulveer Mankia, Shouvik Dass, Andrea Di Matteo, Benazir Saleem, Cédric Duval, Robert Ariëns, Dennis McGonagle
Stay updated with Hemostasis Today.
-
Oct 13, 2026, 21:05Francisco Chacón-Lozsán: Heparin-Induced Thrombocytopenia – When an Anticoagulant Triggers Thrombosis
-
Oct 13, 2026, 21:04Aref Zribi: Isolated Tumor Thrombus and the Role of Prophylactic Anticoagulation
-
Oct 13, 2026, 21:01Alex Larson: Why Normal Bloodwork Does Not Always Tell the Whole Story
-
Oct 13, 2026, 20:58Juan Jauregui-Lozano: How Replication Stress Impairs Red Blood Cell Maturation
-
Oct 13, 2026, 20:55Caitlin Raymond: Understanding Platelet Refractoriness Before Ordering More Platelets
-
Oct 13, 2026, 20:54Sanja Seratlic: How Cow Feeding Systems Influence the Anti-Platelet Properties of Cheddar Cheese
-
Oct 13, 2026, 20:50Ruchika Goel: Cord Blood Red Blood Cells as a Physiologically Aligned Transfusion Strategy
-
Oct 13, 2026, 20:47Sophia Delicou: Strengthening Transfusion Safety Through Advanced Screening and Haemovigilance
-
Oct 13, 2026, 20:45Lydia Pecker: Alloimmunization and Transfusion Indications in Sickle Cell Disease Pregnancy