Alan Nurden: How P-Selectin Inhibition Can Help Thrombus Resolution
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared a post on LinkedIn, about a recent article by Julia B. Kral-Pointner et al, published in AHA/ASA Journals:
“A belated acquaintance for me of a highly recommended study showing how P-Selectin inhibition can help thrombus resolution in mouse models.
This is thought-provoking, but could not this be a strategy to consider to resolve thrombi (arterial or venous) in patients with Glanzmann thrombasthenia and whose platelets lack the alphaIIbbeta3 integrin.
Worth looking at in an appropriate model.”
Title: Reduced Monocyte and Neutrophil Infiltration and Activation by P-Selectin/CD62P Inhibition Enhances Thrombus Resolution in Mice
Authors: Julia B. Kral-Pointner, Patrick Haider, Petra L. Szabo, Manuel Salzmann, Mira Brekalo, Karl H. Schneider, Waltraud C. Schrottmaier, Christoph Kaun, Sonja Bleichert, Attila Kiss, Romana Sickha, Christian Hengstenberg, Kurt Huber, Christine Brostjan, Helga Bergmeister , Alice Assinger, Bruno K. Podesser, Johann Wojta, and Philipp Hohensinner
Read the Full Article on AHA/ASA Journals.
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