Andreas Calatzis: Hidden Differences in Anti-Xa Testing
Andreas Calatzis, Managing Director of Eonis GmbH and Dynabyte GmbH, shared Stago‘s post on LinkedIn, adding:
“Interesting post.
It is indeed very good that not all anti-Xa tests contain dextran sulfate (Stago and Technoclone do not, while Werfen, Hyphen and Siemens do).”
Stago shared a post on LinkedIn:
“Dextran sulfate, a small ingredient with a big impact on Anti‑Xa results
Let’s talk about the key factor behind major Anti‑Xa variability dextran sulfate (DS)
Some Anti‑Xa reagents include DS to dissociate heparin-protein complexes in the tube.
It means that two Anti‑Xa reagents can give two different stories – only one reflects the patient.
The critical issue is that dextran sulfate:
- Does not reflect physiological conditions.
- Can cause major overestimation.
- May change clinical decisions.
Knowing what’s inside your reagent is essential for reliable heparin monitoring.
We will be at ISTH2026, in Paris!
Find out more information on booth 703 and take part to our Meet the Experts session on Sunday 12/07 – 4:00 to 4:30 PM with Pr. Corinne Frere on: Can you trust your Anti-Xa results?”
Title: Reassessment of dextran sulfate in anti-Xa assay for unfractionated heparin laboratory monitoring
Authors: Michael Hardy, Julien Cabo, Antoine Deliège, Jonathan Douxfils, Isabelle Gouin-Thibault, Thomas Lecompte, François Mullier
Title: Factors Influencing Anti-Xa Assays: A Multicenter Prospective Study in Critically Ill and Noncritically Ill Patients Receiving Unfractionated Heparin
Authors: Dominique Lasne, Marie Toussaint-Hacquard, Céline Delassasseigne, Anne Bauters, Claire Flaujac, Philippe Savard, Christine Mouton, Emmanuel De Maistre, Alain Stepanian, Valérie Eschwège, Maxime Delrue, Jean-Louis Georges, Antoine Gros, Alexandre Mansour, Guillaume Leroy, Romain Jouffroy, Matthieu Mattei, Antoine Beurton, Adeline Pontis, Marie Neuwirth, Fabienne Nedelec-Gac, Thomas Lecompte, Emmanuel Curis, Virginie Siguret, Isabelle Gouin-Thibault
Title: Monitoring unfractionated heparin in ECMO and cardiac surgery: the search for a valid reference standard
Authors: Christian F. Weber, Kai Zacharowski, Andreas Calatzis, Marie L. Lindner
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