Andreas Calatzis: Hidden Differences in Anti-Xa Testing
Andreas Calatzis, Managing Director of Eonis GmbH and Dynabyte GmbH, shared Stago‘s post on LinkedIn, adding:
“Interesting post.
It is indeed very good that not all anti-Xa tests contain dextran sulfate (Stago and Technoclone do not, while Werfen, Hyphen and Siemens do).”
Stago shared a post on LinkedIn:
“Dextran sulfate, a small ingredient with a big impact on Anti‑Xa results
Let’s talk about the key factor behind major Anti‑Xa variability dextran sulfate (DS)
Some Anti‑Xa reagents include DS to dissociate heparin-protein complexes in the tube.
It means that two Anti‑Xa reagents can give two different stories – only one reflects the patient.
The critical issue is that dextran sulfate:
- Does not reflect physiological conditions.
- Can cause major overestimation.
- May change clinical decisions.
Knowing what’s inside your reagent is essential for reliable heparin monitoring.
We will be at ISTH2026, in Paris!
Find out more information on booth 703 and take part to our Meet the Experts session on Sunday 12/07 – 4:00 to 4:30 PM with Pr. Corinne Frere on: Can you trust your Anti-Xa results?”
Title: Reassessment of dextran sulfate in anti-Xa assay for unfractionated heparin laboratory monitoring
Authors: Michael Hardy, Julien Cabo, Antoine Deliège, Jonathan Douxfils, Isabelle Gouin-Thibault, Thomas Lecompte, François Mullier
Title: Factors Influencing Anti-Xa Assays: A Multicenter Prospective Study in Critically Ill and Noncritically Ill Patients Receiving Unfractionated Heparin
Authors: Dominique Lasne, Marie Toussaint-Hacquard, Céline Delassasseigne, Anne Bauters, Claire Flaujac, Philippe Savard, Christine Mouton, Emmanuel De Maistre, Alain Stepanian, Valérie Eschwège, Maxime Delrue, Jean-Louis Georges, Antoine Gros, Alexandre Mansour, Guillaume Leroy, Romain Jouffroy, Matthieu Mattei, Antoine Beurton, Adeline Pontis, Marie Neuwirth, Fabienne Nedelec-Gac, Thomas Lecompte, Emmanuel Curis, Virginie Siguret, Isabelle Gouin-Thibault
Title: Monitoring unfractionated heparin in ECMO and cardiac surgery: the search for a valid reference standard
Authors: Christian F. Weber, Kai Zacharowski, Andreas Calatzis, Marie L. Lindner
Stay updated on all scientific advances with Hemostasis Today.
-
Jun 26, 2026, 05:26Maxime Dely: Strengthening Skills in Plasma and Red Cell Exchange
-
Jun 26, 2026, 04:56Recognizing the 2026 ISTH Fundamental Research Career Development Award Recipients
-
Jun 26, 2026, 04:42Jonathan James: Amplifying Voices Across the Bleeding Disorders Community
-
Jun 26, 2026, 04:02Rick Kapur: Advancing Hematology Through Global Collaboration at EHA 2026 and ISBT
-
Jun 26, 2026, 02:06Giovanni Merlino: Scientific Progress in Secondary Stroke Prevention at Udine Stroke Congress 2026
-
Jun 26, 2026, 01:48Michael Stark: Highlights from ISBT 2026 on RBC Transfusion and NEC in Neonates
-
Jun 25, 2026, 23:08Geert Verheyden: Belgium’s Vision for Better Stroke Care Across the Continuum
-
Jun 25, 2026, 21:04Else Charlotte Sandset: Pleasure to Welcome Polish Delegation to Oslo University Hospital Stroke Tour
-
Jun 25, 2026, 19:32Javier M. Floren: A Blood Clot Is One of the Most Impressive Examples of Teamwork You’ll Ever See