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Andrew Lee: Examining Rare Clotting Disorders After Adenovirus-Based COVID-19 Vaccination
Andrew Lee/LinkedIn
Jun 3, 2026, 16:06

Andrew Lee: Examining Rare Clotting Disorders After Adenovirus-Based COVID-19 Vaccination

Andrew Lee, Consultant Epidemiologist at LCP Health Analytics, shared a post on LinkedIn about about a recent article he and his colleagues co-authored, published in Vaccine, adding:

“Delighted to share this recent publication in Vaccine, examining the the real-world association of an adenovirus based COVID-19 vaccine with a rare clotting disorder.

The comparison involved:

  • Four datasets across three countries
  • more than 5 million total individuals
  • 3 distinct comparator groups

Methodological highlights included the use of QBA and negative control outcomes as canaries in the unmeasured confounder coalmine, mechanisms to account for substantial informative censoring, and the use of a supplementary case validation to calculate PPV adjusted incidence rate ratios.

Thanks to Deborah Layton, as well as Joan Forns, Susana Perez-Gutthann and the rest of the RTI team for their sagely guidance in this collaboration.”

Title: Risk of thrombosis with thrombocytopaenia syndrome (TTS) after vaccination with AZD1222: a European VAC4EU post-authorisation safety study

Authors: Joan Forns, Romin Pajouheshnia, Taylor Aurelius, Zachary Bouck, Juan José Carreras, Jungyeon Choi, Albert Cid Royo, Elisa Correcher-Martínez, Silvia Fernandez-Garcia, Catherine Fry, Jordy Gaspersz, Maria Giner-Soriano, Rosa Gini, Anna Girardi, Ron Herings, Wan-Ting Huang, Giulia Hyeraci, Joseph Kim, Samantha Lane, Deborah Layton, Andrew Lee, Thom Lysen, David Martinez, Sima Mohammadi, Denise Morris, Rosa Morros, Dan Ouchi, Jetty Overbeek, Susana Perez-Gutthann, Estel Plana, Robert W. Platt, Giuseppe Roberto, Debabrata Roy, Miriam C.J. Sturkenboom, Amirreza Dehghan Tarazjani, Hae-Won Uh, Arantxa Urchueguía-Fornes, Daniel Weibel, Cristina Rebordosa

Andrew Lee

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adenovirus Albert Cid Royo Amirreza Dehghan Tarazjani Andrew Lee Anna Girardi Arantxa Urchueguía-Fornes AZD1222 bleeding disorders Blood Catherine Fry clotting disorder Covid-19 Cristina Rebordosa Dan Ouchi Daniel Weibel David Martinez Debabrata Roy Deborah Layton Denise Morris Elisa Correcher-Martínez Estel Plana Giulia Hyeraci Giuseppe Roberto Hae-Won Uh Health Hematology Hemostasis Hemostasis News Hemostasis Today Jetty Overbeek Joan Forns Jordy Gaspersz Joseph Kim Juan José Carreras Jungyeon Choi Maria Giner-Soriano Medicine Miriam C.J. Sturkenboom PPV QBA Robert W. Platt Romin Pajouheshnia Ron Herings Rosa Gini Rosa Morros RTI Samantha Lane Silvia Fernandez-Garcia Sima Mohammadi Susana Perez-Gutthann Taylor Aurelius Thom Lysen thrombocytopaenia syndrome thrombosis TTS vaccine Wan-Ting Huang Zachary Bouck
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