Jon Faldasz: Ondansetron May Have Cardiotoxicity Risk Among 5-HT3RAs Due to High Concentration in Cardiac Tissues
Jon Faldasz, Senior Director of Product and Customer Experience at InsightRX, posted on LinkedIn:
”Just dropped: Ondansetron may have outstanding cardiotoxicity risk among 5-HT3RAs due to high concentration in cardiac tissues
Published today in Nature Scientific Reports, Cai et al used the FDA’s Adverse Event Reporting System (FAERS) to review records of cardiotoxicity associated with 5-HT3RA use. They found:
– The different 5-HT3RAs exhibit varying degrees and types of cardiotoxicity
– QT prolongation was most common for ondansetron (granisetron was least common)
– In a subsequent PBPK model extrapolation they estimated that ondansetron concentrations in cardiac tissue were 2.3x higher than plasma.
They suggested that providers might “prioritize low cardiac toxicity 5-HT3RAs” (read: avoid ondansetron) in patients with heart disease.
For my part, FAERS seems like an untapped resource for this type of work, now I’m thinking on what other investigations could make use of it.
Article reference here.”
Title: Cardiotoxicity of different 5-HT3 receptor antagonists analyzed using the FAERS database and pharmacokinetic study
Authors: Yijun Cai, Shaohong Luo, Shen Lin, Xiaoting Huang, Xiangzhen Wang, Lijing Yang, Xiongwei Xu, Xiuhua Weng
Stay updated with Hemostasis Today.
-
Jul 10, 2026, 20:47New Machine Learning Models Improve Prediction of Thrombosis and Bleeding in Cancer – JTH
-
Jul 10, 2026, 20:39Evangelia Petsalaki: New Systems Biology Approach Identifies Biomarkers in Thrombotic APS
-
Jul 10, 2026, 20:29Wolfgang Miesbach: Celebrating Pantep Angchaisuksiri’s Transformative Leadership of the ISTH
-
Jul 10, 2026, 20:17Amy Pantaleo: How Staffing Shortages Are Changing Hemostasis Laboratories
-
Jul 10, 2026, 20:15Gene Nudelman: Early Hemorrhage Control Improves Patient Outcomes
-
Jul 10, 2026, 20:15Lee G.: Can We Transform Dengue Patient Management with Better Coagulation Assessment?
-
Jul 10, 2026, 20:13Shahin Alam: Is Your Coagulant Limiting Your Water Treatment Performance?
-
Jul 10, 2026, 20:12Ali Bozorgi: Our Meta-Analysis on Oral Anticoagulation After AF Ablation Featured in EP Europace
-
Jul 10, 2026, 15:34Joy Celebre: A New Opportunity in Hemostasis Leadership