Cedric Hermans: The Next Generation of FVIIIa-Mimetic Antibodies in Haemophilia A
Cedric Hermans, Co-Chair FVIII/FIX SSC ISTH 2025, shared a post on LinkedIn about recent article he and his colleauges co-authored, published in Blood Reviews, adding:
“It is a great pleasure to share our review, published online today in Blood Reviews:
‘Exploring the evolving landscape of bispecific FVIIIa-mimetic antibodies in haemophilia A’
FVIIIa-mimetic antibodies have transformed haemophilia A care—and the lives of people living with the condition.
Beginning with emicizumab, this therapeutic approach has brought subcutaneous prophylaxis to people with and without FVIII inhibitors, offering protection from bleeding, reducing treatment burden and supporting a more active life.
As the field continues to evolve, our review explores:
- The extensive clinical trial and real-world evidence for emicizumab across all life stages.
- The next generation of bispecific FVIIIa-mimetic antibodies in advanced clinical development.
- Their molecular designs, dosing regimens and distinct preclinical and clinical profiles.
A comprehensive overview for colleagues seeking to understand both the achievements and the future potential of this rapidly evolving therapeutic class.
Many thanks to all my co-authors for this collaboration.
Read the review.”
Title: Exploring the evolving landscape of bispecific FVIIIa-mimetic antibodies in haemophilia A
Authors: Cedric Hermans, Janice M. Staber, Priyanka Raheja, Michaela Lehle, Anna Kiialainen, Christophe Schmitt, Dan Hart, Matthew Locke, Davide Matino, Yesim Dargaud
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