Claudio Laudani on Dual Versus Single Antiplatelet Therapy
Claudio Laudani, Cardiovascular Disease Fellow UNICT, Post-Doc Research Scholar UFHealth JAX, shared on LinkedIn:
”Dual antiplatelet therapy (DAPT) has long been the cornerstone of treatment after PCI, but advances in stent technology and pharmacology are reshaping how we balance ischemic protection and bleeding risk.
In this comprehensive review, we examine:
- The pharmacodynamic rationale of DAPT versus single antiplatelet therapy (SAPT), including differences among P2Y12 inhibitors.
- Clinical evidence comparing DAPT and SAPT strategies in chronic coronary syndrome and acute coronary syndrome patients undergoing PCI.
- The evolving role of early DAPT de-escalation and P2Y12 inhibitor monotherapy in optimizing net clinical benefit.
- Practical considerations for tailoring antiplatelet therapy based on individual ischemic and bleeding risk profiles, and areas where evidence remains limited.
Read more in our review article.”
Article: The pharmacology and clinical evidence for the use of dual versus single antiplatelet therapy
Authors: Claudio Laudani, Luis Ortega-Paz, Francesco Franchi, Fabiana Rollini, Ali Zgheib, Georges El Khoury, Maryam Farahmandsadr, Mohmmad Alawajneh, Marco Spagnolo, Giovanni Occhipinti, Davide Capodanno, Dominick J. Angiolillo
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