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Placental Angiogenic Imbalance in Congenital Heart Disease Pregnancies
Nour Rahnama/LinkedIn
Nov 30, 2025, 14:46

Placental Angiogenic Imbalance in Congenital Heart Disease Pregnancies

Nour Rahnama, Cardiology Resident at the Saint-Luc University Hospital, posted on LinkedIn:

”I’m pleased to share that our latest article, “Placental Angiogenic Imbalance and Its Association With Adverse Outcomes in Congenital Heart Disease Pregnancies,” has just been published in JACC: Advances.

In this prospective study, we investigated biomarkers of placental angiogenesis – sFlt-1 and PlGF – in pregnant women with congenital heart disease (CHD).
Our findings show that women with CHD exhibit higher sFlt-1, lower PlGF, and an elevated sFlt-1/PlGF ratio compared with healthy controls. This angiogenic imbalance was strongly associated with a higher risk of adverse obstetric and neonatal outcomes.

These results reinforce the hypothesis of placental dysfunction in CHD pregnancies, and may open new perspectives for risk stratification and monitoring.

Grateful to my co-authors and collaborators for their contributions.”

Read the full article here.

Title: Placental Angiogenic Imbalance and Its Association With Adverse Outcomes in Congenital Heart Disease Pregnancies

Authors: Nour Rahnama, Arthur Colson, Agnès Pasquet, Damien Gruson, Julie Hotton, Nassiba Menghoum, David Vancraeynest, Christophe Beauloye, Frédéric Debiève, Sophie Pierard

Congenital Heart Disease

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Agnès Pasquet Arthur Colson Cardiology CHD Pregnancies Christophe Beauloye Congenital Heart Disease Congenital Heart Disease Pregnancies Damien Gruson David Vancraeynest Frédéric Debiève Health Heart Health Hematology Hemostasis Hemostasis Today JACC Julie Hotton Medicine Nassiba Menghoum Nour Rahnama Placental Angiogenic Imbalance Saint-Luc University Hospital Sophie Pierard The Journal of the American College of Cardiology thrombosis
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