Danielle Charissa: Functional Genomics Reveals a Causal TWIST1 Variant in Cardiovascular Disease
Danielle Charissa, Senior PhD Strategist at Supreme Optimization, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Arteriosclerosis, Thrombosis, and Vascular Biology, adding:
“PubMed alert: My final first-author paper from my PhD in Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) is officially live!
There are so many stories behind this final product, but I am incredibly proud to share the functional genomics research I did, investigating a causal gene variant for cardiovascular disease in TWIST1.
Yes, this is a single-cell paper. But, it’s a scRNA-seq paper that goes far beyond just ‘identifying a rare disease population’. If you are into genomics, cardiovascular biology, translational research, or have someone you care about who is affected by cardiovascular disease, give it a read.
(Spoiler alert: TWIST1 will make you reconsider what you think you know about HDAC9…)”
Title: Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis
Authors: Danielle C.M. Dy, Thiel Lehman, Benjamin Donald Henson, Jeeya Shah, Jessica Lin, Tiffany Riascos, Robert Wirka
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