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Danielle Charissa: Functional Genomics Reveals a Causal TWIST1 Variant in Cardiovascular Disease
Danielle Charissa/LinkedIn
Sep 9, 2026, 13:01

Danielle Charissa: Functional Genomics Reveals a Causal TWIST1 Variant in Cardiovascular Disease

Danielle Charissa, Senior PhD Strategist at Supreme Optimization, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Arteriosclerosis, Thrombosis, and Vascular Biology, adding:

“PubMed alert: My final first-author paper from my PhD in Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) is officially live!

There are so many stories behind this final product, but I am incredibly proud to share the functional genomics research I did, investigating a causal gene variant for cardiovascular disease in TWIST1.

Yes, this is a single-cell paper. But, it’s a scRNA-seq paper that goes far beyond just ‘identifying a rare disease population’. If you are into genomics, cardiovascular biology, translational research, or have someone you care about who is affected by cardiovascular disease, give it a read.

(Spoiler alert: TWIST1 will make you reconsider what you think you know about HDAC9…)”

Title: Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis

Authors: Danielle C.M. Dy, Thiel Lehman, Benjamin Donald Henson, Jeeya Shah, Jessica Lin, Tiffany Riascos, Robert Wirka

Danielle Charissa

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Arteriosclerosis ATVB Benjamin Donald Henson Blood Cardiology Cardiovascular Disease CVD Danielle C.M. Dy Danielle Charissa HDAC9 Health Hematology Hemostasis Hemostasis News Hemostasis Today Jeeya Shah Jessica Lin Medicine PubMED Robert Wirka scRNA-seq Thiel Lehman thrombosis Tiffany Riascos TWIST1 Vascular Biology
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