Plasma Level Monitoring of DOACs: Balancing Bleeding and Thrombosis Risk
Pall T. Onundarson, Professor Emeritus at Landspitali University Hospital, reposted from Journal of Thrombosis and Haemostasis (JTH) on LinkedIn:
“20 years ago nobody would have been surprised. How else to explain their effect?”
Quoting Journal of Thrombosis and Haemostasis (JTH)’s post on LinkedIn:
“Plasma levels measurement of the 4 direct oral anticoagulants in patients with atrial fibrillation at the time of acute thromboembolic and bleeding events․
This prospective study of 1794 patients with nonvalvular atrial fibrillation found significant interindividual variability in plasma levels of direct oral anticoagulants (DOACs). Low DOAC plasma levels were associated with increased thromboembolic events, while high levels correlated with bleeding events, suggesting plasma level monitoring could help tailor treatment to minimize adverse outcomes.”
Title: Plasma levels measurement of the 4 direct oral anticoagulants in patients with atrial fibrillation at the time of acute thromboembolic and bleeding events
Authors: Cosmo Godino, Riccardo Mazza, Carlo Gaspardone, Alessia Minerva, Rachele Sena, Gianmarco Cozzani, Anna Salerno, Michela Cera, Massimo Slavich, Leila Anna De Lorenzo, Giulio Leo, Giulia Nemola, Annalisa Fattorini, Luciano Crippa, Patrizia Della Valle, Alberto Margonato, Armando D’Angelo
Read the full article here.
Stay updated with Hemostasis Today.
-
Jan 20, 2026, 16:34Fernanda Orsi Explores Brazilian Registry of Thrombotic Thrombocytopenic Purpura
-
Jan 20, 2026, 16:15Tareq Abadl on Bacterial Contamination of Platelets
-
Jan 20, 2026, 15:53Ruzanna Papyan on Neuroblastoma Risk Stratification in Real-World Settings
-
Jan 20, 2026, 13:35Omar Shaltout On Stories Behind Memorable Cases
-
Jan 20, 2026, 13:25Omotola Olasupo and Colleagues Present Comparative Safety of Hemophilia Therapies in Canada
-
Jan 20, 2026, 13:15Benjamin YQ Tan on Precision Lipid Management After Stroke
-
Jan 20, 2026, 13:08Antonio Paul on Blame Game in Transplantation: HLA vs Microbes
-
Jan 20, 2026, 12:33Dario Tuccinardi on Obesity as Cardiovascular Treatment Target
-
Jan 20, 2026, 12:18Ed Shovelin on CRP-A Utilization in Diverse Research Areas