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Plasma Level Monitoring of DOACs: Balancing Bleeding and Thrombosis Risk
Pall T. Onundarson/LinkedIn
Sep 30, 2025, 15:51

Plasma Level Monitoring of DOACs: Balancing Bleeding and Thrombosis Risk

Pall T. Onundarson, Professor Emeritus at Landspitali University Hospital, reposted from Journal of Thrombosis and Haemostasis (JTH) on LinkedIn:

“20 years ago nobody would have been surprised. How else to explain their effect?”

Quoting Journal of Thrombosis and Haemostasis (JTH)’s post on LinkedIn:

“Plasma levels measurement of the 4 direct oral anticoagulants in patients with atrial fibrillation at the time of acute thromboembolic and bleeding events․

This prospective study of 1794 patients with nonvalvular atrial fibrillation found significant interindividual variability in plasma levels of direct oral anticoagulants (DOACs). Low DOAC plasma levels were associated with increased thromboembolic events, while high levels correlated with bleeding events, suggesting plasma level monitoring could help tailor treatment to minimize adverse outcomes.”

Title: Plasma levels measurement of the 4 direct oral anticoagulants in patients with atrial fibrillation at the time of acute thromboembolic and bleeding events

Authors: Cosmo Godino, Riccardo Mazza, Carlo Gaspardone, Alessia Minerva, Rachele Sena, Gianmarco Cozzani, Anna Salerno, Michela Cera, Massimo Slavich, Leila Anna De Lorenzo, Giulio Leo, Giulia Nemola, Annalisa Fattorini, Luciano Crippa, Patrizia Della Valle, Alberto Margonato, Armando D’Angelo

DOACs

Read the full article here.

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Alberto Margonato Alessia Minerva Anna Salerno Annalisa Fattorini Armando D’Angelo Atrial Fibrillation Bleeding Events Carlo Gaspardone Cosmo Godino DOACs Gianmarco Cozzani Giulia Nemola Giulio Leo Health Hematology Hemostasis Today Journal of Thrombosis and Haemostasis JTH Leila Anna De Lorenzo Luciano Crippa Massimo Slavich Medicine Michela Cera Oral Anticoagulants Pall T. Onundarson. Patrizia Della Valle Rachele Sena Riccardo Mazza Thromboembolic Events
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