Erwin Loh: Immunotherapy Reduces Plaque in Arteries of Mice
Erwin Loh, President of Royal Australasian College of Medical Administrators, shared a post on LinkedIn about a recent article by Junedh M. Amrute et al, published in Science:
“Immunotherapy reduces plaque in arteries of mice
Scientists have designed an immunotherapy that reduces plaque in the arteries of mice, presenting a possible new treatment strategy against heart disease.
The antibody-based therapy could complement traditional methods of managing coronary artery disease that focus on lowering cholesterol through diet or medications such as statins.
Such an immunotherapy could especially help patients who already have plaque in their coronary arteries and remain at high risk of heart attack even if they’re able to achieve low cholesterol levels in the blood.
The study is published Jan. 29 in the journal Science.”
Title: Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy
Authors: Junedh M. Amrute, In-Hyuk Jung, Tracy Yamawaki, Wen-Ling Lin, Andrea Bredemeyer, Johanna Diekmann, Sikander Hayat, Xianglong Zhang, Devin L. Wakefield, Xin Luo, Sidrah Maryam, Gyu Seong Heo, Steven Yang, Chang Jie Mick Lee, Chen Wang, Caroline Chou, Christoph Kuppe, Kevin D. Cook, Atilla Kovacs, Vishnu Chintalgattu, Danielle Pruitt, Jose Barreda, Nathan O. Stitziel, Paul Cheng, Yongjian Liu, Rafael Kramann, Daniel Kreisel, Roger S-Y Foo, Ingrid C. Rulifson, Scott Martin, David Grunert, Melissa Thomas, Jixin Cui, Thomas Quertermous, Frank M. Bengel, Simon Jackson, Chi-Ming Li, Brandon Ason, Kory J. Lavine
Read the Full Article on Science
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