Fabrice Cognasse: Improving Hemorrhagic Resuscitation Through Better Understanding of LTOWB
Fabrice Cognasse, Director of Research – Scientific Director at The EFS in Auvergne-Rhône-Alpes and INSERM, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Intensive Care Medicine Experimental, adding:
”New publication!
We are pleased to share our latest study published in Intensive Care Medicine Experimental (CTSA, EFS Inserm SAnté INgéniérie BIOlogie St-Etienne (SAINBIOSE) Ministère des Armées):
Dynamics of platelet activation in cold-stored low-titer group O whole blood over 8 days: insights relative to standard platelet concentrates
As the use of low-titer group O whole blood (LTOWB) continues to expand in trauma and critical care, understanding the biology of platelets during refrigerated storage has become increasingly important.
Aim: To characterize the platelet activation phenotype of cold-stored LTOWB and compare it with standard platelet concentrates throughout 8 days of storage.
Key findings: LTOWB exhibits a distinct platelet activation profile, with progressive basal activation during cold storage while maintaining robust agonist-induced responses through Day 8.
Why does it matter?
These findings provide new insights into the biology of LTOWB and support future studies investigating how storage-related platelet changes may influence hemostasis, immunothrombosis, endothelial interactions, and transfusion-associated lung injury in hemorrhagic resuscitation.
Congratulations to all co-authors and collaborators for this exciting multidisciplinary work!”
Title: Dynamics of platelet activation in cold-stored low-titer group O whole blood over 8 days: insights relative to standard platelet concentrates
Authors: Fabrice Cognasse, Karine Desseux, Véronique Artero, Véronique Duraffourg, Charles-Antoine Arthaud, Amélie Prier, Marie-Ange Eyraud, Victorine Maillot, Damien Crespe, Christophe Martinaud, Sylvain Ausset, Pierre Tiberghien, Laurent Aoustin, Patricia Chavarin, Sébastien Banzet, Nadira Frescaline, Hind Hamzeh-Cognasse
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