University of California/Tufts CTSI
Aug 8, 2025, 17:15
Patent Foramen Ovale and Stroke: David Kent and Andy Wang Break It Down
Vasculearn Network shared an insightful post on LinkedIn:
”ICYMI: PFO and Stroke – Who Benefits from Closure?
About 1 in 4 adults has a PFO, but not everyone needs it closed. A new July 2025 JAMA review reframes PFO closure as targeted, not routine, therapy for select stroke patients.
Key tools guiding treatment:
- RoPE score: Predicts if stroke is PFO-related
- PASCAL system: Adds anatomy to assess stroke causality
Best candidates?
- Age ≤60
- Cryptogenic stroke
- High PASCAL score
- No vascular risk factors
In these patients, closure cuts stroke recurrence risk by up to 90% at 2 years.
Everyone else? Medical therapy still leads with individualized decisions on antiplatelet vs. anticoagulant”
Find the full update on the community.
Read the full article here.
Article: Patent Foramen Ovale and Stroke. A Review
Authors: David M. Kent, Andy Y. Wang
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