Gagan Kukreja Shares A Study On Novel Neuroprotective Agents for Ischemic Stroke
Gagan Kukreja, Lead Medicinal Chemistry Strategist at Syngene International Limited, shared on LinkedIn:
”Holding promise as a treatment of Ischemic stroke (IS), an acute cerebrovascular condition, the publication describes a novel class of pyrazole carboxylic acid borneol esters as novel neuroprotective agents demonstrating potent scavenging activity against nitrogen/oxygen free radicals
With preliminary biosafety studies indicating no obvious organ toxicity, the identified candidate B16, not only restored cerebral blood flow and significantly reduces infarct size in middle cerebral artery occlusion/reperfusion (MCAO/R) mice, but also improved sensory and motor functions, and promotes the recovery of neuronal cells and the blood-brain barrier (BBB) in the brain.
Xueyang Jiang et al”
Read the full article here.
Article: Pyrazole carboxylic acid borneol esters: Novel neuroprotective agents with rapid, efficient brain penetration for the treatment of ischemic stroke
Authors: Siyi Li, Yulu Wu, Wang Chen, Peng Zhu, Xin Lu, Jiaming Li, Xiaodong Ma, Xueyang Jiang
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