Bhavya Venkatesh: Talin Autoinhibition Is Required For Normal Hemostasis
Bhavya Venkatesh, Phd from The University of British Columbia, posted in LinkedIn:
”Excited to share our new publication out now in Platelets Journal
Platelets stick together to form clots using proteins known as integrins, which need to be activated in order to perform this function. Talin is an important protein that facilitates this activation, and talin activity is precisely regulated within the cell. We studied blood clotting using a mouse model that disrupts the mechanism by which talin activity is controlled, expecting to see more integrin activation, and thus faster blood clotting.
What we observed was the opposite of this, these mice showed slower clotting, and the platelets were not able to stick together properly. This suggests for the first time, that the role of talin in platelets is more complex and nuanced than previously thought, and could also be distinct from its role in other cell types.
Thank you to the Kim lab and Guy Tanentzapf at The University of British Columbia for your help and guidance, especially to Kalyan Golla.”
Read the full article here.
Title: Talin autoinhibition is required for normal hemostasis
Authors: Bhavya Venkatesh, Kalyan Golla, Felix Hong, Amanda Haage, Hugh Kim, Guy Tanentzapf
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