Indunil Karunarathna Explores Clinical and Diagnostic Significance of D-Dimer
Indunil Karunarathna, Founder of Uva Clinical Research Lab (UCRL), shared on LinkedIn:
”Clinical and Diagnostic Significance of D-Dimer From Coagulation Physiology to Multisystem Applications
Uva Clinical Research Lab 2025 Uva Clinical Anaesthesia and Intensive Care ISSN 2827-7198, 2025
D-dimer, a fibrin degradation product, has emerged as a critical biomarker in evaluating thrombotic and fibrinolytic activity within the human body.
Biochemically, D-dimer forms when cross-linked fibrin undergoes plasmin-mediated proteolysis, reflecting the dynamic balance between clot formation and breakdown.
Its high sensitivity and low specificity confer significant clinical utility in ruling out venous thromboembolism (VTE), disseminated intravascular coagulation (DIC), and other hypercoagulable states, though interpretation must be context-specific.
This review provides a comprehensive analysis of the physiological mechanisms of D-dimer formation, the principles of coagulation and fibrinolysis, and the kinetics of its clearance.
We discuss specimen collection, assay methodologies, age-adjusted cutoffs, and factors influencing test accuracy.
Clinical applications are explored in depth, including its role in diagnosing pulmonary embolism, deep vein thrombosis, DIC, stroke, COVID-19–related coagulopathy, and venom-induced consumption coagulopathy.
Integration with risk stratification tools such as the Wells and Geneva scores, as well as the Pulmonary Embolism Rule-out Criteria (PERC), is highlighted to optimize diagnostic pathways.
The review emphasizes both the diagnostic and prognostic implications of D-dimer in diverse patient populations, advocating for judicious use alongside clinical judgment.”
Read the full article here.
Article: Clinical and Diagnostic Significance of D-Dimer From Coagulation Physiology to Multisystem Applications
Authors: Indunil Karunarathna
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 13, 2026, 20:17Julia R. Coleman: Fantastic First Day at ISTH 2026
-
Jul 13, 2026, 20:11Ruah Alyamany: Combination Therapy Improves Quality of Life in ITP
-
Jul 13, 2026, 19:47Brian O Mahony: Two-Year Results of BBM-H901 Gene Therapy Presented at ISTH 2026
-
Jul 13, 2026, 19:37Sara Zalghout: Connecting With Colleagues From All Over the World at ISTH 2026
-
Jul 13, 2026, 18:54Alfonso J. Tafur: New Evidence on Perioperative Anticoagulation in Cancer at ISTH 2026
-
Jul 13, 2026, 18:42Jessica Garcia: Thrombin Generation in Type 3 VWD With an Inhibitor on Emicizumab
-
Jul 13, 2026, 18:19Fionnuala Ní Áinle: High-Quality Evidence for DVT Diagnosis in Pregnancy at ISTH 2026
-
Jul 13, 2026, 17:39Pascal Boulanger: Send a Postcard to Your Lab Staff From ISTH 2026
-
Jul 13, 2026, 17:21Stefano Navarro: Presenting Our Recently Published Article at ISTH 2026