Jukka Partanen: How HLA Heterodimers Refine Genetic Risk in Lichen Planus
Jukka Partanen, Research Professor At Finnish Red Cross Blood Service, shared on LinkedIn about a recent article he and his colleagues co-authored, published in HLA, adding:
“HLA alleles are the strongest single genetic factor related to genetic susceptibility to many immunological diseases.
We have multiple closely-related HLA genes that additionally are extremely variable making detailed mapping analyses difficult.
In our recent fine mapping study on HLA and lichen planus we demonstrated that the standard conditional approach does not reveal everything.
The high risk HLA DQ molecules formed trans heterodimers that additionally adjusted the disease risk.
Large biobank cohorts, here FinnGen, greatly help these studies.”
Title: Fine-Mapping of HLA Effects in Oral and Non-Oral Lichen Planus
Authors: Jarmo Ritari, Mary Pat Reeve, Maria Siponen, Mari Vehviläinen, Tuula Salo, Kazutoyo Osoegawa, Marcelo Fernandez Viña, Benjamin Goudey, Jukka Partanen, Emmanuel J. M. Mignot
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 26, 2026, 15:48Melissa Hollo: Postpartum Depression is More Than the “Baby Blues”
-
Aug 26, 2026, 15:46Raghavendra Rao: The Link Between Neuropathy and Chronic Venous Disease
-
Aug 26, 2026, 15:43Laurent Bertoletti: Long Term Benefits and Safety of Rehabilitation in Pulmonary Arterial Hypertension
-
Aug 26, 2026, 15:41Tamer Hellou: Chromosome 1q Gain Signals High Long-Term Risk in AL Amyloidosis
-
Aug 26, 2026, 15:04Sequential Efgartigimod and Eltrombopag Achieve Durable Response in Refractory ITP – Platelets Journal
-
Aug 26, 2026, 14:46Holly O’Byrne: A Framework for Developing and Managing Prehospital Blood Programs
-
Aug 26, 2026, 14:32Eleftherios Mylonakis: Earlier Intervention, Better Risk Stratification, Stronger BP Control
-
Aug 26, 2026, 14:32Bringing ISTH 2026 Research to the Global Scientific Community
-
Aug 26, 2026, 14:23Joseph R. Shaw: Thrombin Generation and the Pharmacodynamics of Oral Anticoagulants