Julia Sjöberg: ROCK1 Inhibition and Red Blood Cell Recovery After Chemotherapy
Julia Sjöberg, PhD Student in medical science at Lund University, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:
“I’m excited to share that my first author paper is now published in its final form in Blood Advances!
In this study, we explored how chemotherapy affects blood stem cells and their ability to regenerate the blood system, with a focus on delayed red blood cell recovery.
We identified a mechanism involving caspase 1 mediated activation of ROCK1 that contributes to delayed erythroid recovery after 5 FU treatment.
Inhibiting ROCK1 improved red blood cell recovery in mice.
These findings shed light on how stem cells respond to chemotherapy and suggest a potential avenue for future research into chemotherapy-associated anaemia.
A big thank you to my supervisors Els Mansell and Valgardur Sigurdsson, and to all my co authors and colleagues at Lund University and Lund Stem Cell Center for all their support and contributions!”
Title: Chemotherapy-related anemia is regulated through caspase-1–mediated ROCK1 activation
Authors: Julia Sjöberg, Anna Rydström, Oscar Hedberg, Tariq Enver, Jonas Larsson, Els Mansell, Valgardur Sigurdsson
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