Lindsey George: Blood Study Links AAV-Derived FVIII Activity to Clinical Outcomes
Lindsey George, Assistant Professor of Pediatrics at University of Pennsylvania, Director of Clinical In Vivo Gene Therapy at Children’s Hospital of Philadelphia, shared Anna R. Sternberg’s post on LinkedIn:
“Congrats on seeing this through Anna and to all co-authors on this work!
Here we investigated the biochemical function of transgene-derived FVIII post AAV gene transfer as well as its hemostatic function in mice and relative correlation with clinical data.”
Anna R. Sternberg, Research Associate Scientist at Children’s Hospital of Philadelphia, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:
“6 years in the making with Lindsey George.
The pre-print for our research understanding the biochemical mechanism behind the AAV-derived FVIII assay discrepancy observed in patients is now available to read in Blood!”
Title: One-stage Assay Factor VIII Activity Reflects AAV-Derived Factor VIII-Enhanced Thrombin Activation and Predicts Phenotype
Authors: Anna R Sternberg, Connor T. Watson, Robert J Davidson, Marianne Uguen, Anna Kiialainen, Lindsey A. George
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